{"schema_version":1,"experiment_id":"eoa_inverse_innovation_exp03_full320_20260801","cell_id":"computability_boundary_mapping__pharmacology_toxicology","trajectory_id":"R","attempt_index":0,"candidate_sha256":"dbb4b3586f6526c1c9549b90cfb5c94c3fc4496eafc9e55774f20bddebeb255d","gates":{"G1":{"status":"PASS","reason":"The problem is independently recognizable as an overclaim about executable toxicity-model reachability, with observable interface behavior and consequential false-safety risk even without the archetype framing."},"G2":{"status":"PASS","reason":"The candidate preserves the open model class, universal terminating guarantee, model-relative boundary, constructive and impossibility evidence paths, enforceable decidable regions, and explicitly weaker fallbacks."},"G3":{"status":"PASS","reason":"Enforcing fragment membership, checking the reduction, routing by guarantee, and preserving UNKNOWN directly change which verdicts may be issued and prevent timeout from becoming a safety conclusion."},"G4":{"status":"PASS","reason":"Every archetype component is translated, and the selected mechanisms have differentiated causal, operational, testing, and safety roles with coherent counterfactual-removal statements."},"G5":{"status":"PASS","reason":"Unverified scientific and reduction claims are explicitly bounded as hypotheses or inferences. The candidate proposes independent checking before any unrestricted impossibility claim and does not present empirical biology as proof of undecidability."},"G6":{"status":"PASS","reason":"The problem falsifier tests whether the alleged universal computability problem exists, while the intervention falsifier separately tests whether the boundary workflow improves label discrimination and prevents false-safe outputs."},"G7":{"status":"PASS","reason":"Authority is limited, the initial test uses synthetic models, consequential dosing and release decisions are excluded, and concrete halt, rollback, logging, and manual-review conditions are supplied."}},"scores":{"structural_fit":{"score":4,"reason":"The proposal instantiates the archetype's quantifiers, computation model, proof obligations, restricted regions, status lattice, and honest fallback behavior with unusually complete correspondence."},"domain_fidelity":{"score":3,"reason":"The transfer is appropriately limited to formal executable PK/PD and toxicodynamic models and distinguishes model correctness from biological validity, though the expressive language and endpoint semantics remain to be instantiated."},"causal_plausibility":{"score":3,"reason":"The workflow plausibly prevents false universal assurances through enforceable routing and labelled uncertainty, conditional on a valid reduction and usable restricted fragments."},"component_translation":{"score":4,"reason":"The complete component set receives domain-specific realizations, including proof review, uncertainty residue, recheck triggers, and the complexity follow-on."},"adversarial_survival":{"score":4,"reason":"The candidate directly addresses the finite-class rival, the organism-versus-program analogy break, restricted-fragment utility failure, abstraction alarm burden, label erasure, and false-safe outcomes."},"reframing_gain":{"score":4,"reason":"It replaces an undifferentiated simulation-performance problem with a model-relative classification of exact, restricted, one-sided, bounded, and unresolved guarantees."},"practicality_testability":{"score":3,"reason":"A synthetic bounded pilot, finite corpus, fragment checker, reduction review, output-label audit, and rollback path are executable, although concrete language and corpus definitions remain pending."},"expected_value_risk":{"score":3,"reason":"The synthetic-only first step offers substantial learning with limited direct harm, while formalization error, unusable fragments, alert fatigue, and downstream label loss remain material risks."},"novelty_evidence":{"score":0,"reason":"Prior art is explicitly unsearched, so no evidence supports a novelty claim."}},"weighted_total":83.75,"disposition":"DEEP_RESEARCH","fabrication_findings":[],"weak_dimensions":["novelty_evidence"],"actionable_critique":[{"priority":"HIGH","issue":"The decisive source-to-target reduction is specified as an obligation but not exhibited in the packet.","repair":"Instantiate the executable language and endpoint predicate, provide the total computable encoding and answer-preservation argument, and obtain independent review before asserting unrestricted undecidability.","evidence_boundary":"The present candidate supports a safe research workflow and a conditional boundary claim, not a completed impossibility theorem."},{"priority":"MEDIUM","issue":"The usefulness and domain coverage of the proposed decidable fragments are not yet demonstrated.","repair":"Define mechanically enforceable fragments and measure their coverage of decision-relevant synthetic model patterns together with abstraction precision and UNKNOWN frequency.","evidence_boundary":"Structural plausibility is established, but operational utility in computational toxicology remains hypothetical."},{"priority":"MEDIUM","issue":"No prior-art evidence supports distinctiveness of the composition.","repair":"Compare the workflow with existing formal verification, hybrid-systems reachability, pharmacometric model qualification, and computational-toxicology assurance practices before making a novelty claim.","evidence_boundary":"The packet explicitly marks prior art as unsearched."}],"repairs":[],"improvement_attribution":{"kind":"NONE","reason":"This is the original attempt, and the packet reports no change to either the problem identifier or the causal-lever identifier; remaining limitations concern evidence maturation rather than revision-attributable improvement."},"trajectory_replacement":false,"arm_guess":"MECHANISM_PACKET","recommendation":"SUCCESS","tester_summary":"The candidate is a structurally faithful and safety-bounded transfer that clearly separates formal model reachability from biological reality. It is suitable for deep research because its unrestricted boundary remains conditional on a checked reduction, its restricted fragments require utility testing, and novelty is unevidenced."}