{"schema_version":1,"experiment_id":"eoa_inverse_innovation_exp03_full320_20260801","cell_id":"invariant_mode_decomposition_design__pharmacology_toxicology","trajectory_id":"R","attempt_index":0,"candidate_sha256":"ad2079b21c2539806851c511f4618c5bcf6876d3e0c0f23209f0f57215335121","gates":{"G1":{"status":"PASS","reason":"The coupled, subthreshold toxicity-detection problem is stated independently of modal terminology and could be established or falsified without adopting the archetype."},"G2":{"status":"PASS","reason":"The proposal maps an explicit longitudinal transformation, state vector, approximate invariant directions, modal responses, selection rules, residual checks, drift monitoring, and interpretation limits into the toxicology setting."},"G3":{"status":"PASS","reason":"The decomposition changes what joint trajectories become detectable, while stability and harm-weighted sensitivity connect those trajectories to assay, monitoring, dose, and schedule hypotheses subject to confirmatory testing."},"G4":{"status":"PASS","reason":"All archetype components receive bounded domain translations, selected mechanisms have distinct necessary roles, and rejected mechanisms are excluded for reasons consistent with their limitations."},"G5":{"status":"PASS","reason":"Scientific claims are labeled as hypotheses or inferences, empirical performance is not asserted, prior-art status is disclosed as unsearched, and biological mechanism is not inferred from mathematical loadings."},"G6":{"status":"PASS","reason":"The problem falsifier tests whether coupled dynamics add detectable signal beyond ordinary review, whereas the intervention falsifier separately tests whether mode-ranked actions outperform the nearest rival."},"G7":{"status":"PASS","reason":"The authorized first step is retrospective and decision-neutral, prospective changes remain with named authorities, affected parties are identified, and explicit halt and rollback conditions preserve ordinary review."}},"scores":{"structural_fit":{"score":4,"reason":"The candidate preserves the archetype's transformation, modal, selection, residual, drift, and bounded-interpretation structure with unusually complete traceability."},"domain_fidelity":{"score":3,"reason":"The state variables, repeat-dose setting, pathology linkage, protocol governance, and toxicology decision context are credible, though actual modal reproducibility remains compound- and dataset-dependent."},"causal_plausibility":{"score":3,"reason":"Joint transition modes could reveal persistent harm patterns hidden from univariate review, but actionable effects of dose or schedule changes remain appropriately unproven."},"component_translation":{"score":4,"reason":"Every named component is translated into a specific toxicology object, rule, diagnostic, or governance constraint without substituting generic analytics language."},"adversarial_survival":{"score":4,"reason":"The candidate directly addresses nonlinearity, non-normal transients, sparse sampling, scaling, measurement error, small gaps, mode rotation, rare-signal loss, and biological overinterpretation."},"reframing_gain":{"score":4,"reason":"The proposal shifts review from isolated biomarker thresholds to propagation of harm-relevant joint states and makes hidden persistence, amplification, and model invalidity decision-visible."},"practicality_testability":{"score":3,"reason":"A blinded retrospective shadow comparison is concrete and non-disruptive, but thresholds, sample sufficiency, conditioning limits, and harm-weighted budgets still require preregistration."},"expected_value_risk":{"score":3,"reason":"The decision-neutral first test offers useful detection evidence at limited immediate risk, with residual safeguards against false reassurance and unauthorized exposure changes."},"novelty_evidence":{"score":0,"reason":"Prior art is explicitly unsearched, so distinctiveness from existing multivariate toxicology, state-space, and longitudinal safety methods is unsupported."}},"weighted_total":83.75,"disposition":"DEEP_RESEARCH","fabrication_findings":[],"weak_dimensions":["novelty_evidence"],"actionable_critique":[{"priority":"MEDIUM","issue":"Distinctiveness from existing longitudinal multivariate toxicology and state-space safety methods has not been established.","repair":"Conduct a bounded prior-art comparison focused on transition-mode stability, harm-weighted modal sensitivity, spectral validity gates, and governed toxicology use.","evidence_boundary":"This closed-book evaluation supports structural novelty only as an unverified possibility and supplies no literature-based novelty conclusion."}],"repairs":[],"improvement_attribution":{"kind":"NONE","reason":"This is the original candidate, with no prior problem, causal lever, or registered repair against which improvement can be attributed."},"trajectory_replacement":false,"arm_guess":"MECHANISM_PACKET","recommendation":"SUCCESS","tester_summary":"The candidate is structurally complete, domain-bounded, falsifiable, and safety-governed. Its main unresolved weakness is evidence of novelty rather than internal fit or testability."}