{"schema_version":1,"experiment_id":"eoa_inverse_innovation_exp04_retrieval_first_paired20_20260802","cell_id":"negative_space_design__neuroscience","hypothesis_id":"H1","search_queries":["stroke somatosensory discrimination training rest interval blocks retention rehabilitation","poststroke sensory retraining spaced practice intertrial interval tactile discrimination","wakeful rest consolidation stroke rehabilitation sensory learning","difficulty adaptive rest intervals rehabilitation training patent stroke sensory","\"somatosensory\" \"inter-block\" rest learning stroke","\"tactile discrimination\" \"wakeful rest\" consolidation","patent adaptive rest interval rehabilitation difficulty training","stroke rehabilitation distributed practice rest schedule motor learning retention guideline"],"sources":[{"source_id":"PA1","title":"US20140287389A1: Systems and methods for real-time adaptive therapy and rehabilitation","publisher":"Google Patents","url":"https://patents.google.com/patent/US20140287389A1/en","source_class":"PATENT","claims_supported":["Discloses rehabilitation exercises with an optional rest-pose wait phase between repetitions.","Discloses changing wait time from prior performance metrics within therapist-specified minimum and maximum bounds.","Substantially anticipates the hypothesis's difficulty-linked rest-duration component, but concerns motion exercises rather than post-stroke sensory discrimination or consolidation outcomes."]},{"source_id":"PA2","title":"Consolidation of human skill linked to waking hippocampo-neocortical replay","publisher":"Cell Reports / PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/34107255/","source_class":"PRIMARY_RESEARCH","claims_supported":["Healthy participants practiced a motor sequence in 10-second periods interleaved with 10-second waking-rest intervals.","Skill gains occurred during interleaved rest, and sequence-specific neural replay during rest predicted rapid offline gains.","The study establishes brief rest as a consolidation window but does not concern stroke, sensory discrimination, difficulty-adaptive intervals, active-filler comparison, or 24-hour retention."]},{"source_id":"PA3","title":"SENSory re-learning of the UPPer limb (SENSUPP) after stroke: development and description of a novel intervention using the TIDieR checklist","publisher":"Trials / Springer Nature","url":"https://link.springer.com/article/10.1186/s13063-021-05375-6","source_class":"PRIMARY_RESEARCH","claims_supported":["Describes therapist-guided post-stroke training containing touch discrimination, proprioception, tactile object recognition, graded difficulty, and repeated 20-minute blocks.","Each 2.5-hour session includes a fixed 15-minute break between 60 minutes of sensory relearning and 60 minutes of task-specific training.","It does not report difficulty-adapted stimulus-free gaps at every block transition, an active-filler comparator, or a 24-hour retention endpoint."]},{"source_id":"PA4","title":"Rehabilitation and recovery: principles of rehabilitation","publisher":"National Clinical Guideline for Stroke","url":"https://www.strokeguideline.org/chapter/rehabilitation-and-recovery-principles-of-rehabilitation/?id=228","source_class":"OFFICIAL_GUIDANCE","claims_supported":["Official stroke guidance recognizes dose, duration, frequency, pacing, variable schedules, fatigue, tolerance, and individualized delivery as rehabilitation considerations.","It states that evidence about intensity for sensory effects of stroke is less developed than evidence for physical and functional rehabilitation.","It does not establish protected, difficulty-adaptive stimulus-free intervals as sensory-retraining practice."]},{"source_id":"PA5","title":"Current clinical practice in managing somatosensory impairments and the use of technology in stroke rehabilitation","publisher":"PLOS One","url":"https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0270693","source_class":"PRIMARY_RESEARCH","claims_supported":["A survey of 132 stroke therapists found task-specific, movement, balance, proprioceptive, object-discrimination, and tactile exercises in clinical use.","The reported practice inventory does not identify consolidation-oriented, difficulty-adaptive stimulus-free block transitions as a common somatosensory intervention.","The survey supports the clinical relevance of sensory retraining while limiting any assertion that the nominated scheduling mechanism is established practice."]},{"source_id":"PA6","title":"Does Sensory Retraining Improve Sensation and Sensorimotor Function Following Stroke: A Systematic Review and Meta-Analysis","publisher":"Frontiers in Neuroscience","url":"https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2019.00402/pdf?isPublishedV2=false","source_class":"AUTHORITATIVE_SECONDARY","claims_supported":["Reviewed 38 randomized trials of post-stroke sensory interventions, including six active sensory-training trials.","Active interventions included graded sensory discrimination and perceptual-learning protocols, but the review found the evidence limited and heterogeneous.","Its intervention tables do not identify a trial comparing difficulty-adaptive stimulus-free interblock rest with equal-duration active filler and 24-hour retention."]}],"proximity":"SUBSTANTIAL_COLLISION","closest_analogues":[{"name":"Performance-adaptive rehabilitation wait times","similarity":"PA1 combines therapist-bounded rehabilitation, prior-performance measurement, inter-repetition rest, and performance-related adjustment of wait duration; this closely overlaps the scheduling lever.","remaining_difference":"It adapts waits in motion exercise delivery for execution and fatigue management, not explicitly to protect consolidation after post-stroke sensory-discrimination blocks, and it does not test active filler or delayed sensory retention.","source_ids":["PA1"]},{"name":"Block-structured post-stroke sensory relearning with a scheduled break","similarity":"SENSUPP already combines stroke sensory discrimination, therapist guidance, graded difficulty, repeated 20-minute blocks, and a fixed 15-minute break inside a session.","remaining_difference":"The break is fixed and separates major training components rather than being an explicitly cued, stimulus-free, difficulty-adaptive consolidation interval evaluated against time-matched active filler.","source_ids":["PA3","PA6"]},{"name":"Brief waking-rest consolidation during interleaved practice","similarity":"PA2 supplies direct mechanistic evidence that brief rest interleaved with practice supports rapid offline gains and neural replay.","remaining_difference":"Its healthy-participant motor-sequence paradigm lacks stroke, somatosensory rehabilitation, difficulty adaptation, an active-filler control, and the nominated 24-hour retention pattern.","source_ids":["PA2"]},{"name":"Distributed and individually paced stroke rehabilitation","similarity":"Stroke guidance already treats pacing, variable schedules, fatigue, tolerance, and individualized therapy delivery as legitimate design variables.","remaining_difference":"Guidance emphasizes rehabilitation dose and participation and does not prescribe consolidation-specific empty intervals in sensory retraining.","source_ids":["PA4","PA5"]}],"overlapping_components":["Therapist-guided post-stroke sensory-discrimination training","Block-structured repetitive practice","Graded or individualized task difficulty","Scheduled rest within rehabilitation sessions","Performance-related adaptation of rehabilitation wait duration","Brief waking rest as a potential consolidation period","Delayed assessment of sensory-training effects"],"remaining_contrastive_claim":"In therapist-guided post-stroke somatosensory discrimination training, explicitly cued stimulus-free gaps whose duration is determined by preceding-block difficulty will improve 24-hour retention over equal-duration active filler without changing immediate performance.","claim_falsifier":"The contrast would be falsified by a dated trial, protocol, patent, or deployed system that already combines post-stroke sensory-discrimination blocks, preceding-difficulty-based stimulus-free interval duration, a time-matched active-filler comparison, and delayed retention testing, or by an adequately powered trial showing no retention advantage over active filler.","problem_support":"MODERATE","recommendation":"RESEARCH","world_novelty_boundary":"This bounded eight-query ordinary-web review found the central components separately and in close rehabilitation combinations, producing substantial collision, but no opened source contained the full contrastive combination; this is not a worldwide novelty determination because specialized patent classification searching, subscription databases, trial-registry expansion, dissertations, non-English literature, and exhaustive citation-family review were not completed."}