{"schema_version":1,"experiment_id":"eoa_inverse_innovation_exp04_retrieval_first_paired20_20260802","cell_id":"negative_space_design__neuroscience","round_index":0,"assessments":[{"hypothesis_id":"H1","search_queries":["post-stroke sensory retraining intertrial interval retention stimulus-free rest primary study","stroke sensory discrimination training spaced practice rest intervals consolidation","somatosensory discrimination learning post stroke retention training trial blocks","intertrial interval perceptual learning consolidation sensory rehabilitation stroke"],"sources":[{"source_id":"H1-S1","title":"SENSe: Study of the Effectiveness of Neurorehabilitation on Sensation: A Randomized Controlled Trial","publisher":"Journal of Neurologic Physical Therapy / SAGE Publications","url":"https://journals.sagepub.com/doi/10.1177/1545968310397705","source_class":"PRIMARY_RESEARCH","claims_supported":["A randomized trial tested perceptual-learning-based somatosensory discrimination training in 50 stroke survivors.","Training used repeated graded discrimination, intermittent feedback, and 15–20-minute sensory-task blocks, but did not report randomized stimulus-free versus active-filler intervals.","Sensory improvements were assessed immediately and at six-week and six-month follow-up."]},{"source_id":"H1-S2","title":"How short breaks help the brain learn new skills","publisher":"U.S. National Institutes of Health","url":"https://www.nih.gov/news-events/nih-research-matters/how-short-breaks-help-brain-learn-new-skills","source_class":"GOVERNMENT_OR_REGULATOR","claims_supported":["NIH summarizes evidence that brief waking rest periods contribute to consolidation during motor-skill learning.","The reported work concerns general motor learning rather than post-stroke sensory discrimination rehabilitation."]},{"source_id":"H1-S3","title":"Tactile angle discriminability improvement: roles of training time intervals and different types of training tasks","publisher":"Experimental Brain Research / Springer Nature","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6879964/","source_class":"PRIMARY_RESEARCH","claims_supported":["Training intervals have been experimentally manipulated in tactile perceptual learning.","The study supplies a non-stroke tactile-learning analogue but does not test difficulty-adaptive empty intervals in stroke rehabilitation."]},{"source_id":"H1-S4","title":"Interventions for perceptual disorders following stroke","publisher":"Cochrane","url":"https://www.cochrane.org/evidence/CD007039_interventions-perceptual-disorders-following-stroke","source_class":"AUTHORITATIVE_SECONDARY","claims_supported":["The review identified 18 small heterogeneous randomized trials of post-stroke perceptual interventions.","The review found the evidence insufficient and called for longer-term outcomes; it did not identify protected stimulus-free interblock intervals as an established intervention."]}],"closest_analogue":"Brief wakeful-rest consolidation in motor learning, combined with interval manipulation in tactile perceptual learning and established post-stroke sensory-discrimination training.","overlap":"The analogue set includes repeated sensory or motor practice, temporal gaps between practice episodes, consolidation or retention outcomes, and delayed follow-up.","remaining_difference":"The testable difference is a post-stroke sensory-retraining trial that randomizes explicitly cued, stimulus-free interblock intervals against equal-duration active filler, adapts interval duration to preceding-block difficulty, and tests 24-hour retention while holding immediate performance and training exposure constant.","classification":"POSSIBLE_DISTINCTION","disposition":"ADVANCE","rationale":"The component ideas are established separately, but the shallow search did not reveal their direct combination in post-stroke sensory retraining. This is provisional rather than a novelty inference from search failure; the next review should specifically determine whether any stroke somatosensory protocol or trial has compared passive rest with time-matched active filler at block transitions."},{"hypothesis_id":"H2","search_queries":["adaptive sparse EEG display seizure onset localization channels visualization study","epilepsy EEG channel selection visualization seizure onset localization interface","reduced channel montage seizure onset detection distributed onset clinical review","EEG visualization channel hiding focus mode epilepsy surgery planning"],"sources":[{"source_id":"H2-S1","title":"American Clinical Neurophysiology Society Guideline 3: A Proposal for Standard Montages to Be Used in Clinical EEG","publisher":"American Clinical Neurophysiology Society","url":"https://www.acns.org/UserFiles/file/EEGGuideline3Montage.pdf","source_class":"OFFICIAL_GUIDANCE","claims_supported":["Clinical montages should be simple and readily comprehended while providing adequate spatial coverage.","The guideline recommends at least 16 simultaneous channels, the full 21-electrode 10–20 placement, multiple montage classes, and additional coverage when needed for localization.","Standard montage selection already changes which derivations are displayed, but the guideline does not evaluate a candidate-only focus view."]},{"source_id":"H2-S2","title":"Efficacy of a Reduced Electroencephalography Electrode Array for Detection of Seizures","publisher":"Neurocritical Care / Springer Nature","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3869310/","source_class":"PRIMARY_RESEARCH","claims_supported":["Two blinded epileptologists visually reviewed reduced-array EEG clips.","The reduced array achieved 70% sensitivity and 96% specificity for seizure detection, demonstrating both the feasibility and information-loss risk of sparse review."]},{"source_id":"H2-S3","title":"Effects of a reduction of the number of electrodes in the EEG montage on the number of identified seizure patterns","publisher":"Clinical Neurophysiology Practice / Elsevier","url":"https://pubmed.ncbi.nlm.nih.gov/35301386/","source_class":"PRIMARY_RESEARCH","claims_supported":["Two experts compared full and eight-lead views of 95 seizure and 95 control sequences.","Reducing the montage lowered seizure-pattern sensitivity from 0.76 to 0.65 and missed patterns across several anatomical seizure categories."]}],"closest_analogue":"Blinded expert review of reduced EEG montages, in which fewer simultaneously visible signals reduce display complexity but can also reduce seizure sensitivity.","overlap":"Both approaches present experts with a sparse subset of multichannel electrophysiology, seek faster or clearer interpretation, and must guard against losing spatially distributed evidence.","remaining_difference":"The proposed view retains all acquired data, temporarily hides only noncandidate channels, preserves electrode-location context, provides one-action restoration, and evaluates onset-localization agreement plus distributed-onset detection rather than merely seizure detection. Bounded research question: do existing clinical iEEG workstations, patents, or human-factors studies already implement and validate this exact reversible candidate-channel focus workflow?","classification":"INDETERMINATE_RESEARCH_NEEDED","disposition":"ADVANCE","rationale":"Reduced-montage review is a close and cautionary analogue, while ACNS guidance shows that selective montage display is routine. The retrieved sources do not establish whether reversible candidate-only channel focus is already a clinical product feature or validated localization method, so a targeted workstation-manual, patent, and human-factors search is required before treating the difference as substantive."},{"hypothesis_id":"H3","search_queries":["DBS programming washout period carryover randomized settings Parkinson's blinded study","deep brain stimulation programming washout stimulation off interval symptom target bradykinesia tremor","DBS parameter comparison order effects washout period study","guideline deep brain stimulation programming washout interval official"],"sources":[{"source_id":"H3-S1","title":"Deep Brain Stimulation Programming for Movement Disorders: Current Concepts and Evidence-Based Strategies","publisher":"Frontiers in Neurology","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6558426/","source_class":"AUTHORITATIVE_SECONDARY","claims_supported":["DBS programming guidance explicitly notes that symptom responses occur on different time scales.","Rigidity may return within about one minute after stimulation cessation, while bradykinesia responds more slowly, and this must be considered before subsequent tests."]},{"source_id":"H3-S2","title":"Association of Deep Brain Stimulation Washout Effects With Parkinson Disease Duration","publisher":"JAMA Neurology / American Medical Association","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5148628/","source_class":"PRIMARY_RESEARCH","claims_supported":["Bradykinesia was repeatedly measured during a 50-minute stimulation-off interval.","DBS benefit washed out in fast and slow phases with substantial patient-level variation related to disease duration.","The authors recommend conservative or individually adjusted washout intervals in DBS trials."]},{"source_id":"H3-S3","title":"Return of bradykinesia after subthalamic stimulation ceases: Relationship to electrode location","publisher":"Movement Disorders / Wiley","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3375109/","source_class":"PRIMARY_RESEARCH","claims_supported":["The study quantified symptom decay after STN stimulation was switched off.","It discusses prior evidence supporting one-to-two-hour washout periods and demonstrates clinically relevant variation in washout behavior."]},{"source_id":"H3-S4","title":"Multiple input algorithm-guided Deep Brain stimulation-programming for Parkinson’s disease patients","publisher":"npj Parkinson's Disease / Springer Nature","url":"https://www.nature.com/articles/s41531-022-00396-7","source_class":"PRIMARY_RESEARCH","claims_supported":["A randomized crossover double-blind programming study imposed defined wash-in periods before symptom scoring.","Suggested settings were scored after at least 30 seconds during optimization, while randomized comparisons used 30-minute wash-in periods.","The workflow already protects transition time from immediate scoring and uses symptom measurements to compare settings."]}],"closest_analogue":"DBS programming and crossover protocols that impose symptom-dependent washout or wash-in periods and delay scoring after stimulation changes.","overlap":"The prior work already recognizes physiological carryover, reserves stimulation-off or transition time, delays assessment, measures symptom return, and recommends individualized or conservative interval selection.","remaining_difference":"The narrow residual difference is formalizing a patient-specific observable exit criterion and testing whether that rule changes final setting selection versus nominal immediate transitions; the underlying protected washout intervention is already explicit in the literature.","classification":"OBVIOUS_COLLISION","disposition":"REJECT","rationale":"The causal lever is not merely adjacent to established practice: primary DBS studies directly measure off-state washout, document individual variation, prescribe washout or wash-in intervals, and defer scoring. Adding a label, protected scheduling rule, or explicit exit criterion does not preserve enough difference for this screen."},{"hypothesis_id":"H4","search_queries":["neurofeedback transfer trials without feedback intermittent feedback faded feedback primary study","neurofeedback no-feedback transfer blocks feedback removed training randomized","faded neurofeedback schedule self regulation transfer trial","neurofeedback guidelines transfer runs no feedback official consensus"],"sources":[{"source_id":"H4-S1","title":"Mixed-Effects Modeling of Neurofeedback Self-Regulation Performance: Moderators for Learning in Children with ADHD","publisher":"Applied Psychophysiology and Biofeedback / Springer Nature","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5885491/","source_class":"PRIMARY_RESEARCH","claims_supported":["Training blocks intermingled visible-feedback trials with transfer trials in which the feedback stimulus was absent.","The percentage of no-feedback transfer trials was progressively increased across sessions, reaching 50% in later blocks.","Task cues and end-of-trial reward remained available during transfer trials."]},{"source_id":"H4-S2","title":"Analysis of individual differences in neurofeedback training illuminates successful self-regulation of the dopaminergic midbrain","publisher":"Communications Biology / Springer Nature","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9391365/","source_class":"PRIMARY_RESEARCH","claims_supported":["Each neurofeedback session included no-feedback baseline and transfer runs around feedback-training runs.","The study identifies regulation without feedback as the outcome of primary interest for transfer beyond training.","Task context was retained through condition words while the moving feedback display was omitted."]},{"source_id":"H4-S3","title":"Maintenance and generalization of 40-Hz EEG biofeedback effects","publisher":"Biofeedback and Self-Regulation / Springer","url":"https://pubmed.ncbi.nlm.nih.gov/7397274/","source_class":"PRIMARY_RESEARCH","claims_supported":["Participants were tested for control of EEG activity without feedback after feedback retraining.","Five of six participants demonstrated significant no-feedback control, and transfer to a problem-solving task was also assessed."]}],"closest_analogue":"Faded neurofeedback protocols that progressively interleave explicitly cued transfer trials with no visible feedback while retaining task context.","overlap":"Existing protocols deliberately remove the feedback signal, label or cue the regulation condition, restore feedback in later trials, and evaluate self-regulation without feedback as transfer.","remaining_difference":"Potential differences are restoration based on a predefined performance trigger, explicit malfunction-versus-transfer framing, equalized total feedback exposure, and a blinded clinical transfer outcome; these are implementation and trial-design refinements around an already established no-feedback-transfer intervention.","classification":"OBVIOUS_COLLISION","disposition":"REJECT","rationale":"Interleaved and progressively increased no-feedback epochs are already described as transfer training, not merely post-training assessment. Retained task cues and later feedback restoration also substantially reproduce the proposed meaning-of-absence structure."},{"hypothesis_id":"H5","search_queries":["aphasia naming therapy cue latency delayed cue independent retrieval study","aphasia response time clinician wait time naming cue delay trial","aphasia naming treatment response contingent cueing delay errorless learning","speech language therapy aphasia wait time cueing naming guideline"],"sources":[{"source_id":"H5-S1","title":"How Much Time Do People With Aphasia Need to Respond During Picture Naming? Estimating Optimal Response Time Cutoffs Using a Multinomial Ex-Gaussian Approach","publisher":"Journal of Speech, Language, and Hearing Research / American Speech-Language-Hearing Association","url":"https://pubs.asha.org/doi/10.1044/2019_JSLHR-19-00255","source_class":"PRIMARY_RESEARCH","claims_supported":["The study estimates person-specific optimal picture-naming response-time cutoffs.","It establishes that an appropriate naming deadline varies across people with aphasia, but does not test adaptive clinician silence as treatment."]},{"source_id":"H5-S2","title":"Errorless, Errorful, and Retrieval Practice for Naming Treatment in Aphasia: A Scoping Review of Learning Mechanisms and Treatment Ingredients","publisher":"American Journal of Speech-Language Pathology / American Speech-Language-Hearing Association","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10023178/","source_class":"AUTHORITATIVE_SECONDARY","claims_supported":["The review identifies effortful retrieval, cue scheduling, and feedback timing as consequential treatment ingredients.","Five retrieval-practice studies provided feedback after an eight-second naming trial.","The review reports uncertainty about which variations in cueing and retrieval opportunity are essential for learning."]},{"source_id":"H5-S3","title":"Test-Enhanced Learning Versus Errorless Learning in Aphasia Rehabilitation: Testing Competing Psychological Principles","publisher":"Journal of Experimental Psychology: Learning, Memory, and Cognition / American Psychological Association","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4476962/","source_class":"PRIMARY_RESEARCH","claims_supported":["Retrieval practice was directly compared with repetition-based errorless learning in aphasia rehabilitation.","Retrieval practice produced better delayed naming performance, supporting a benefit from allowing effortful retrieval rather than supplying the response immediately."]},{"source_id":"H5-S4","title":"Phonological and orthographic facilitation of word-retrieval in aphasia: Immediate and delayed effects","publisher":"Aphasiology / Taylor & Francis","url":"https://www.tandfonline.com/doi/abs/10.1080/02687040143000483","source_class":"PRIMARY_RESEARCH","claims_supported":["Items not named within five seconds were assigned to extra-time or cue conditions.","The design provides a direct analogue for comparing additional uncued response time with clinician-provided word-retrieval cues."]}],"closest_analogue":"Aphasia retrieval-practice protocols that allow an uncued naming window before feedback, combined with person-specific modeling of optimal response-time cutoffs.","overlap":"Prior work already protects several seconds for independent retrieval, delays feedback or cues, compares extra time with cueing, and links effortful retrieval to delayed learning.","remaining_difference":"The testable difference is a treatment policy that continuously adapts the prompt-to-cue interval to the individual and ends silence on a response, an observable distress signal, or a patient-specific maximum, then jointly evaluates uncued generalization to untrained items and distress against fixed immediate cueing.","classification":"POSSIBLE_DISTINCTION","disposition":"ADVANCE","rationale":"Fixed retrieval windows, extra-time controls, and individualized descriptive cutoffs are close analogues, but the shallow search did not identify a response- and distress-contingent adaptive silence policy tested as naming therapy. The next review should determine whether adaptive cueing-hierarchy protocols already use patient-state termination rules and report both untrained-item generalization and distress."}],"nominated_ids":["H1","H2","H5"],"replenishment_recommended":false}