{"schema_version":1,"experiment_id":"eoa_inverse_innovation_exp04_retrieval_first_paired20_20260802","cell_id":"negative_space_design__neuroscience","arm":"RETRIEVAL_FIRST","round_index":0,"hypotheses":[{"hypothesis_id":"H1","title":"Protected rest gaps in post-stroke sensory training","problem":"Dense, uninterrupted sensory-retraining trials may let successive stimuli interfere with consolidation.","affected_stakeholder":"Stroke survivors receiving sensory rehabilitation","workflow_boundary":"Between trial blocks in therapist-guided sensory retraining","failure_mode":"The next stimulus overwrites or masks learning from the preceding block.","unit_of_analysis":"Trial-block transition","causal_lever":"Insert explicitly cued, stimulus-free intervals whose duration depends on preceding block difficulty.","archetype_mapping":"A blank-or-rest frame protects temporal empty space so the prior sensory signal can settle before stimulation resumes.","expected_value":"If interference is material, delayed discrimination and retention could improve without adding training trials.","falsifiable_claim":"Compared with equal-duration active filler, cued stimulus-free intervals will improve 24-hour retention while immediate performance remains unchanged.","diversity_rationale":"Targets temporal consolidation during rehabilitation, unlike visualization, stimulation washout, feedback transfer, or clinician-patient turn taking.","mechanism_slugs":["blank_or_rest_frame","pause_in_speech"],"search_questions":["Do stimulus-free intertrial or interblock intervals improve retention in post-stroke sensory rehabilitation?","What interval lengths separate consolidation benefits from disengagement or fatigue?"]},{"hypothesis_id":"H2","title":"Channel-cleared review for epilepsy treatment planning","problem":"Dense multichannel neural recordings can bury treatment-relevant seizure onset patterns under simultaneously visible activity.","affected_stakeholder":"Epileptologists selecting targets for surgery or neurostimulation","workflow_boundary":"Initial review of candidate seizure-onset epochs","failure_mode":"Display crowding causes reviewers to miss or mislocalize the earliest reproducible transition.","unit_of_analysis":"Reviewer-by-seizure-epoch interpretation","causal_lever":"Temporarily hide noncandidate channels while preserving location context and one-action recovery of the full montage.","archetype_mapping":"Focus mode and whitespace create protected visual absence around candidate channels without deleting recoverable evidence.","expected_value":"If visual competition drives errors, localization agreement and review speed could improve while full evidence remains accessible.","falsifiable_claim":"A reversible channel-cleared view will increase blinded inter-rater agreement on onset localization without reducing detection of distributed onsets versus the full montage.","diversity_rationale":"Changes a clinical evidence-display boundary and measures interpretation agreement, rather than altering patient exposure or therapeutic dialogue.","mechanism_slugs":["focus_mode_or_control_hiding","whitespace"],"search_questions":["Have sparse or adaptive EEG displays improved seizure-onset localization accuracy?","Which channels and annotations must remain visible to avoid concealing distributed onset?"]},{"hypothesis_id":"H3","title":"Designed stimulation-off voids in DBS programming","problem":"Residual effects from one deep-brain-stimulation setting may contaminate assessment of the next setting.","affected_stakeholder":"People with movement disorders and clinicians programming DBS","workflow_boundary":"Transition between candidate stimulation settings","failure_mode":"Insufficient washout makes carryover look like benefit or harm from the new parameter set.","unit_of_analysis":"Parameter-setting transition","causal_lever":"Reserve a symptom-appropriate stimulation-off interval, label its purpose, and forbid scoring until its exit criterion is met.","archetype_mapping":"An architectural void translated into protocol time gives the unstimulated interval a boundary, function, and protected status against schedule compression.","expected_value":"If carryover biases programming, cleaner comparisons could reduce selection of falsely favorable settings.","falsifiable_claim":"Protected off-intervals will reduce order effects in blinded symptom scores and change final setting selection more often than nominal immediate transitions.","diversity_rationale":"Uses physiological washout at a device-setting transition, with order effects as the outcome rather than learning or perceptual clarity.","mechanism_slugs":["architectural_void","blank_or_rest_frame"],"search_questions":["What washout periods are required for different DBS targets and symptoms?","Do current programming studies quantify setting-order or carryover effects?"]},{"hypothesis_id":"H4","title":"Framed no-feedback epochs in neurofeedback therapy","problem":"Continuous neurofeedback may teach control that depends on the feedback display rather than transferring to daily life.","affected_stakeholder":"Patients using neurofeedback for symptom self-regulation","workflow_boundary":"Transition from acquisition to transfer within a treatment session","failure_mode":"Performance collapses when external feedback disappears because absence is abrupt or interpreted as system failure.","unit_of_analysis":"Feedback-on versus feedback-off training epoch","causal_lever":"Interleave clearly signaled no-feedback epochs, retain task context, and restore feedback after a predefined performance trigger.","archetype_mapping":"Empty-state design makes absent feedback meaningful, while recoverability and reintroduction prevent the blank interval from reading as malfunction.","expected_value":"If cue dependence limits transfer, deliberate absence could improve unassisted regulation outside treatment.","falsifiable_claim":"Participants trained with framed no-feedback epochs will outperform continuous-feedback controls on a blinded no-feedback transfer test despite equal feedback exposure.","diversity_rationale":"Manipulates informational absence during skill transfer and tests cue independence, distinct from rest, display decluttering, washout, and conversational latency.","mechanism_slugs":["empty_state_design","focus_mode_or_control_hiding"],"search_questions":["Do intermittent or faded neurofeedback schedules improve transfer without feedback?","How can no-feedback epochs be framed without revealing performance or increasing anxiety?"]},{"hypothesis_id":"H5","title":"Adaptive clinician silence in aphasia naming therapy","problem":"Clinicians may supply cues or complete responses before a person with aphasia has enough time to retrieve a word independently.","affected_stakeholder":"People with aphasia in naming therapy","workflow_boundary":"Interval after a naming prompt and before the first clinician cue","failure_mode":"Premature cueing suppresses effortful retrieval; excessive silence instead produces distress or abandonment.","unit_of_analysis":"Prompt-to-cue interval within a naming trial","causal_lever":"Protect an adaptive silent latency and end it on a response, a distress signal, or a patient-specific maximum.","archetype_mapping":"Facilitation silence with a meaning-of-absence check withholds the higher-power speaker's contribution while retaining an ethical reintroduction trigger.","expected_value":"If premature assistance limits retrieval practice, independent naming and generalization could improve without increasing distress.","falsifiable_claim":"Adaptive protected silence will increase uncued correct retrieval on untrained items versus fixed immediate cueing, without worsening session-level distress ratings.","diversity_rationale":"Targets interpersonal power and response timing at the single-trial level, with language generalization and distress as joint outcomes.","mechanism_slugs":["facilitation_silence","pause_in_speech"],"search_questions":["How does cue latency affect independent word retrieval and generalization in aphasia therapy?","Which observable signals can distinguish productive search from confusion or distress?"]}]}