{"schema_version":1,"experiment_id":"eoa_inverse_innovation_exp06_four_proposal_generalization60_20260803","source_assessment_id":"invariant_mode_decomposition_design__biology_ecology:P5:v0","cell_id":"invariant_mode_decomposition_design__biology_ecology","proposal_index":5,"qualification":"EMPIRICAL_PARTNER_CANDIDATE","criteria":{"specific_differentiated_claim":{"status":"YES","reason":"The remaining application-level claim is specific and falsifiable: within one fixed organoid line and developmental window, a mode-aligned cue schedule must move a reproducible off-target transition coordinate and outperform standard, sham, single-cue, response-surface, and direct-prediction comparators without violating predefined biological or model-validity guardrails."},"credible_problem_signal":{"status":"YES","reason":"Independent organoid studies document material batch, maturation, patterning, composition, fidelity, and reproducibility variation, while NIH has funded a dedicated center for standardized organoid development and real-time protocol optimization."},"identifiable_partner_or_adopter":{"status":"YES","reason":"An organoid research laboratory with an approved cell line, microplate differentiation workflow, imaging and assay access, and a protocol owner is a concrete experimental partner class; the NIH Standardized Organoid Modeling Center is an identifiable prospective adopter or funder."},"partner_access_is_necessary":{"status":"YES","reason":"The unresolved questions concern batch-specific mode reproducibility, estimator identifiability, cue responsiveness, protected-state effects, workflow fit, and comparative performance under proprietary laboratory conditions. They cannot be resolved through public research alone and require approved cultures, assays, protocol parameters, and independent validation batches."},"safe_authorized_first_step":{"status":"YES","reason":"The proposed first step is limited to research-only cultures, existing approved factors, bounded perturbations, and one approved protocol. A local protocol owner can authorize it, while biosafety, tissue-governance, quality, and cell-line custodians retain veto authority; work must not begin until those local approvals are confirmed."},"bounded_decisive_empirical_design":{"status":"YES","reason":"The preregistered two-batch microplate design freezes the model and thresholds before blinded validation, uses explicit nonmodal comparators, measures intermediate and endpoint outcomes, and defines decisive rejection conditions for irreproducible modes, absent directional response, comparator non-superiority, or any protected-state or model-validity failure."},"no_material_negative_gate":{"status":"YES","reason":"All substantive verified gates are YES, including problem support, adopter credibility, distinct testability, bounded evidence, and absence of an unresolved safety or authority stop. Cost scope is uncertain but is not the sole reason for partnering and does not negate the bounded empirical test."},"not_merely_more_research":{"status":"YES","reason":"The next action is a concrete partner-run experiment with a fixed line, developmental window, perturbation envelope, preregistered estimators and thresholds, randomized blinded comparator arms, protected endpoints, and explicit success and falsification rules."}},"uncertainty_types":["ADOPTER_PULL","INCREMENTAL_EFFECT","WORKFLOW_FIT","DATA_ACCESS","COST_SCOPE"],"partner_profile":"An organoid research laboratory or standardized-organoid center operating an approved, established research cell line and fixed differentiation protocol, with protocol-owner authority, biosafety and tissue-governance oversight, microplate culture capacity, imaging and targeted molecular-assay access, and quantitative modeling support.","required_access":"Approved research-only organoid cultures; the fixed protocol, cue ranges, developmental timing, line provenance, and batch metadata; randomized identification and validation wells; imaging, viability, morphology, stress, contamination, lineage, and targeted molecular measurements; assay-core and quantitative staff; and documented local protocol-owner, biosafety, tissue-governance, quality, and custodian authorization.","bounded_empirical_test":"Run one preregistered identification batch and one independent blinded validation batch in a single approved line and developmental window. Use bounded perturbations of existing cues to estimate and freeze the transition model, mode-matching rules, conditioning and separation limits, residual budget, protected-state guardrails, targeted mode, and schedules. Randomize validation wells among the standard protocol, sham timing change, best single-cue adjustment, response-surface schedule, direct multivariate-prediction schedule, and mode-aligned schedule.","success_condition":"Across independent-batch and resampling checks, the targeted off-target mode remains reproducible and adequately conditioned; the mode-aligned schedule moves its held-out coordinate in the preregistered direction and improves the preregistered multivariate trajectory or endpoint-envelope outcome over both the best nonmodal schedule and direct predictor, while all maturation, composition, viability, morphology, stress, contamination, residual, spectral-separation, drift, and scope guardrails pass.","falsification_condition":"Reject the incremental claim if the mode rotates, disappears, is ill-conditioned, or lacks separation; if the permitted schedule does not move it as predicted; if the schedule fails to outperform the best nonmodal schedule and direct predictor on the preregistered held-out endpoint; or if any protected biological state, contamination, residual, drift, authorization, or scope limit fails.","rationale":"This is an appropriate empirical-partner case because credible external evidence establishes the organoid reproducibility problem and adjacent methods, but the differentiated organoid-specific modal gate remains genuinely unresolved. The decisive evidence depends on access to approved live cultures, laboratory-specific protocol conditions, matched assays, and independent batches. The proposed collaboration is bounded, research-only, comparator-based, governed by independent vetoes, and capable of either supporting or rejecting the remaining claim."}