{"schema_version":1,"experiment_id":"eoa_inverse_innovation_exp06_four_proposal_generalization60_20260803","cell_id":"catalytic_pathway_enablement__chemistry_materials","portfolio_valid":true,"proposal_assessments":[{"proposal_index":1,"complete":true,"causally_faithful":true,"materially_distinct":true,"reason":"Operationally specifies the PET transformation, kinetic barrier, immobilized reusable enzyme, feed interface, selectivity, controls, turnover assay, capacity metering, regeneration and retirement, safety authority, falsifiers, and a bounded next experiment. Its causal path is retained enzymatic active sites lowering the bond-cleavage barrier across successive material batches."},{"proposal_index":2,"complete":true,"causally_faithful":true,"materially_distinct":true,"reason":"Operationally specifies eligible diffraction records, the recurring cross-instrument reconciliation barrier, a reusable reference-coupon and versioned-transform gateway, bounded corrections, exception handling, counterfactuals, coupon and software requalification, stewardship, falsifiers, and an offline probe. It preserves raw evidence and scientific criteria while repeatedly lowering calibration and interpretation effort."},{"proposal_index":3,"complete":true,"causally_faithful":true,"materially_distinct":true,"reason":"Operationally specifies the metastable-liquid-to-qualified-crystal transformation, recurring nucleation barrier, nonstoichiometric microtextured insert, formulation and thermal interface, phase selectivity, matched controls, complete-melt reset, reconditioning and retirement, safety limits, falsifiers, and a multi-cycle probe. The insert lowers the heterogeneous nucleation barrier and returns for reuse without supplying bulk crystal material."},{"proposal_index":4,"complete":true,"causally_faithful":true,"materially_distinct":true,"reason":"Operationally specifies the eligible-dossier-to-bounded-decision transformation, repeated translation and coordination barrier, reusable governed service, intake and escalation rules, unchanged substantive authorities, capacity and conflict controls, post-case regeneration, counterfactual measures, falsifiers, and a nonbinding shadow trial. Its human and informational facilitator is explicitly treated as exhaustible, governed, recoverable capacity."}],"pairwise_assessments":[{"proposal_a":1,"proposal_b":2,"same_problem":false,"same_intervention":false,"independent_opportunity":true,"key_difference":"Proposal 1 addresses slow PET bond cleavage with an immobilized enzyme basket acting on matter; proposal 2 addresses repeated cross-instrument diffraction reconciliation with reference coupons, a calibration transform, and validation acting on measurement records. Their barriers, facilitators, outputs, and causal paths are independent."},{"proposal_a":1,"proposal_b":3,"same_problem":false,"same_intervention":false,"independent_opportunity":true,"key_difference":"Proposal 1 accelerates irreversible polymer depolymerization through enzyme-mediated bond cleavage; proposal 3 triggers a reversible salt-hydrate phase transition through heterogeneous nucleation on a microtextured insert. They affect different materials problems through different catalytic mechanisms and produce different outcomes."},{"proposal_a":1,"proposal_b":4,"same_problem":false,"same_intervention":false,"independent_opportunity":true,"key_difference":"Proposal 1 is a reactor intervention lowering a chemical kinetic barrier in PET fines; proposal 4 is a governed human-and-informational service lowering evidence-translation and coordination burdens in solvent-substitution review. Neither intervention is a feature, population variant, or implementation detail of the other."},{"proposal_a":2,"proposal_b":3,"same_problem":false,"same_intervention":false,"independent_opportunity":true,"key_difference":"Proposal 2 standardizes diffraction data by estimating and validating bounded instrument-response corrections; proposal 3 initiates crystallization and heat release by providing reusable physical nucleation sites. One transforms information through metrological calibration, while the other transforms material state through interfacial nucleation."},{"proposal_a":2,"proposal_b":4,"same_problem":false,"same_intervention":false,"independent_opportunity":true,"key_difference":"Proposal 2 resolves instrument-dependent measurement variation through physical references and a deterministic software transform; proposal 4 resolves cross-functional review friction through dossier translation, routing, and accountable specialist judgment. Their affected problems, interventions, decision processes, and causal mechanisms differ materially."},{"proposal_a":3,"proposal_b":4,"same_problem":false,"same_intervention":false,"independent_opportunity":true,"key_difference":"Proposal 3 addresses delayed crystallization in thermal storage with a regenerable nucleation surface; proposal 4 addresses delayed governance decisions for coating-solvent trials with a regenerating review service. The former lowers a physical nucleation barrier, while the latter lowers recurring informational and coordination barriers."}],"replacement_indices":[],"rationale":"Every proposal is operationally complete, instantiates the full catalytic cycle rather than merely adding capacity or relaxing a constraint, and includes a specified permitted transformation, recurring barrier, reusable selective facilitator, interface, counterfactual validation, turnover and capacity controls, degradation monitoring, regeneration or retirement, and governed stopping rules. All six pairs differ simultaneously in the affected problem, intervention, and causal path, so the four proposals are mutually independent."}