{"schema_version":1,"experiment_id":"eoa_inverse_innovation_exp12_substrate_denial72_20260805","research_id":"eoa_inverse_innovation_exp12_light_screen_20260805","cell_id":"constraint_propagation_and_decoupling__chemistry_materials","search_lanes":{"direct_problem_and_intervention":{"queries":["microfluidic capillary network reaction induced clogging precipitation self pruning branches","patent capillary card mixing sequence compatibility screening gel precipitation"],"source_ids":["SRC2","SRC3"],"no_result_note":"No retained source disclosed the complete combination of a formulation-order prefix tree, failure-generated descendant exclusion, isolated siblings, and terminal recomposition; this phrase-level miss is not evidence of novelty."},"synonyms_and_historical_terms":{"queries":["paper microfluidic timed shut off valve hydrogel swelling capillary flow","microfluidic tree serial dilution mixing combinations branching network chemical screening","Factors Affecting Alkaline Sodium Silicate Gelation"],"source_ids":["SRC1","SRC2","SRC3"],"no_result_note":null},"products_practices_and_standards":{"queries":["paper microfluidic combinatorial screening formulations mixing order gel precipitation","site:pubchem.ncbi.nlm.nih.gov sodium silicate hazard corrosive","site:sigmaaldrich.com sodium silicate solution safety data sheet acid incompatibility"],"source_ids":["SRC2","SRC4"],"no_result_note":null},"component_combination":{"queries":["sodium silicate calcium acid order of addition gel precipitation coating formulation","microfluidic reaction induced valve precipitation gel plug autonomous flow stop capillary","Hydrogel Microvalves as Control Elements for Parallelized Enzymatic Cascade Reactions journal"],"source_ids":["SRC1","SRC3"],"no_result_note":null}},"sources":[{"source_id":"SRC1","title":"Factors Affecting Alkaline Sodium Silicate Gelation for In-Depth Reservoir Profile Modification","publisher":"Energies (MDPI)","url":"https://www.mdpi.com/1996-1073/7/2/568","source_type":"PRIMARY_RESEARCH","claims_supported":["Sodium-silicate gelation time and strength depend on pH, silicate concentration, temperature, shear, and divalent-ion concentration.","Calcium and magnesium ions accelerate gelation, while metal-silicate precipitation can occur in the presence of divalent ions.","Gelation changes an initially mobile solution into a cloudy, increasingly viscous three-dimensional network, supporting the underlying possibility of flow-arresting incompatibility."]},{"source_id":"SRC2","title":"An integrated microfluidic device for two-dimensional combinatorial dilution","publisher":"Lab on a Chip, Royal Society of Chemistry","url":"https://pubs.rsc.org/en/content/articlelanding/2011/lc/c1lc20449a","source_type":"PRIMARY_RESEARCH","claims_supported":["A tree-like microfluidic generator can prepare combinations of three input solutions at low volume.","The demonstrated device uses intermediate reservoirs, active injection, and arrays of isolated test chambers for combinatorial screening.","It establishes adjacent art for tree-based multicomponent preparation but not order-prefix sharing or failure-driven pruning."]},{"source_id":"SRC3","title":"Hydrogel Microvalves as Control Elements for Parallelized Enzymatic Cascade Reactions in Microfluidics","publisher":"Micromachines (MDPI)","url":"https://www.mdpi.com/2072-666X/11/2/167","source_type":"PRIMARY_RESEARCH","claims_supported":["Swollen hydrogel elements can fully block microchannels and determine which parallel reaction compartment receives flow.","Spatially separated serial and parallel reaction compartments can support alternative multistep chemical paths.","Its valves are fabricated control elements switched electrothermally, rather than incompatibility products that autonomously prune a shared-prefix tree."]},{"source_id":"SRC4","title":"Sodium Silicate | Na2O3Si | CID 23266","publisher":"PubChem, National Library of Medicine","url":"https://pubchem.ncbi.nlm.nih.gov/compound/Sodium-silicate","source_type":"OFFICIAL_GUIDANCE","claims_supported":["Commercial sodium-silicate solutions are strongly alkaline and may be corrosive or strongly irritating to skin, eyes, and the respiratory tract.","The principal soluble-silicate hazard is alkalinity, supporting hood, eye, skin, containment, and waste controls for a small laboratory test.","The hazard information supports controlled laboratory review rather than an intrinsic prohibition on the proposed sub-10-milliliter experiment."]}],"problem_evidence":{"status":"PARTLY_SUPPORTED","finding":"The underlying incompatibility is visible: acidification, divalent ions, concentration, temperature, and shear can materially change sodium-silicate gelation or cause precipitation, and multicomponent microfluidic screening is established. The retained sources do not directly document the exact four-component coating, reproducible addition-order failures, or redundant descendant vial trials, so those proposal-specific premises remain to be demonstrated.","source_ids":["SRC1","SRC2"]},"closest_prior_art":[{"name":"Tree-like two-dimensional combinatorial dilution microdevice","source_ids":["SRC2"],"overlap":"Uses a microfluidic tree, three inputs, low reagent volume, and isolated terminal chambers to generate and screen multicomponent mixtures.","remaining_difference":"It varies concentration through active injection and treats inputs as non-reacting; it does not encode addition-order prefixes, let reaction failures close shared trunks, propagate exclusions, or perform matched final-composition recomposition checks."},{"name":"Hydrogel-valved parallel microfluidic cascade reactor","source_ids":["SRC3"],"overlap":"Combines serial and parallel reaction compartments with hydrogel-induced channel blockage that selects fluid pathways.","remaining_difference":"Its preinstalled valves are externally switched and route predetermined enzyme cascades; the tested formulation does not itself generate a plug, and there is no common-prefix dependency tree or automatic exclusion of all failed-prefix descendants."},{"name":"Controlled sodium-silicate gelation and precipitation practice","source_ids":["SRC1"],"overlap":"Uses the same binder chemistry and demonstrates that lowered pH and divalent ions can accelerate gel formation or produce metal-silicate precipitation capable of reducing permeability.","remaining_difference":"It characterizes and manages gelation for reservoir treatment rather than using localized incompatibility as a passive screening computation across addition sequences."}],"prior_art_disposition":"ADJACENT_PRIOR_ART","contrastive_claim_remaining":"For matched formulations whose failed prefixes remain irreversible throughout a preregistered observation interval, a capillary network encoding shared addition-order prefixes will use the formulation-generated plug itself to arrest every dependent descendant while isolated sibling paths continue, and surviving paths will reproduce matched full-mixture and cure outcomes in terminal wells. The retained tree mixers and microvalves do not jointly demonstrate that failure-coupled prefix propagation and recomposition behavior.","contrastive_claim_falsifier":"Falsify the claim if blinded matched-vial testing shows that card plugs occur without irreversible vial failure, any vial-failed prefix fails to arrest all encoded descendants, viable siblings are contaminated or arrested, a later addition reproducibly rescues a pruned prefix, or terminal-well classifications fail to agree with matched complete-mixture and coupon outcomes beyond the preregistered tolerance.","gates":{"adequate_source_search":{"status":"PASS","rationale":"The bounded search covered the proposal directly, older and synonymous terms, microfluidic combinatorial practices, passive or hydrogel valving, sodium-silicate gelation chemistry, and official hazard information. Four opened sources from three publishers were retained; three are primary research and one is official guidance. This supports only a coarse screen.","source_ids":["SRC1","SRC2","SRC3","SRC4"]},"supported_problem":{"status":"PASS","rationale":"Primary research supports chemically sensitive sodium-silicate gelation and precipitation and establishes a practical motivation for small-volume multicomponent screening, although the exact coating and sequence-dependence premise is only partly supported and must be tested.","source_ids":["SRC1","SRC2"]},"distinct_testable_claim":{"status":"PASS","rationale":"Adjacent art separately demonstrates tree-based combinatorial preparation and hydrogel-based path blockage, but the remaining claim distinctly couples a formulation-generated irreversible prefix failure to passive descendant arrest, sibling survival, and terminal recomposition. Each element has observable failure criteria.","source_ids":["SRC1","SRC2","SRC3"]},"bounded_next_test":{"status":"PASS","rationale":"A single card with no more than sixteen paths and under ten milliliters, run against duplicated matched microvials, can measure reference flow, prefix classification, descendant arrest, sibling isolation, terminal mixture state, and coupon cure. The test is small, reversible, and capable of falsifying both chemical monotonicity and card fidelity.","source_ids":["SRC1","SRC2","SRC3"]},"no_obvious_safety_or_authority_stop":{"status":"PASS","rationale":"No intrinsic stop is apparent for a sub-10-milliliter benchtop comparison using already approved reagents under supervisor and laboratory-safety-officer authority. Sodium silicate's alkalinity and corrosive/irritant potential require hood, splash protection, compatible containment, SDS review for the selected hardener and pigments, and approved waste handling; unknown toxic or gas-evolving combinations remain excluded.","source_ids":["SRC4"]}},"screen_survival":true,"world_novelty_boundary":"This bounded public-web screen found adjacent rather than colliding art, but it cannot establish world novelty, patentability, market size, expert acceptance, or realized value. Unindexed publications, patents using different terminology, proprietary formulation systems, and unsearched non-English literature may contain closer prior art."}