{"schema_version":1,"experiment_id":"eoa_inverse_innovation_exp12_substrate_denial72_20260805","research_id":"eoa_inverse_innovation_exp12_light_screen_20260805","cell_id":"context_keyed_representation_switching__chemistry_materials","search_lanes":{"direct_problem_and_intervention":{"queries":["photoresponsive molecularly imprinted membrane enantioselective separation switch wavelength R S enantiomer","light responsive chiral molecularly imprinted membrane reversible enantioselectivity","photoresponsive enantioselective molecularly imprinted polymer switchable adsorption enantiomer"],"source_ids":["SRC1","SRC2","SRC3"],"no_result_note":null},"synonyms_and_historical_terms":{"queries":["photoswitchable molecularly imprinted polymer enantiomer recognition azobenzene","photo-responsive stationary phase control elution order enantiomers","photochromic chiral recognition polymer reverse enantiomer selectivity light"],"source_ids":["SRC1","SRC2","SRC3"],"no_result_note":null},"products_practices_and_standards":{"queries":["photoswitchable chiral stationary phase enantiomer separation light irradiation","molecularly imprinted membrane chiral separation enantiomers review","OSHA ultraviolet radiation laboratory safety UV"],"source_ids":["SRC2","SRC4"],"no_result_note":null},"component_combination":{"queries":["reversal of enantioselectivity light photoswitchable receptor separation","light-controlled enantioselective separation membrane azobenzene","photoinduced reversal enantioselectivity adsorption porous material R S","dual template molecularly imprinted membrane enantiomers R S competitive adsorption"],"source_ids":["SRC1","SRC2","SRC3"],"no_result_note":"No retained source disclosed the exact combination of one covalent imprinted membrane whose two wavelength-selected states reverse preference between both enantiomers while reciprocally suppressing the inactive recognition geometry."}},"sources":[{"source_id":"SRC1","title":"Switching the enantioselectivity of nanoporous host materials by light","publisher":"Royal Society of Chemistry","url":"https://pubs.rsc.org/en/content/articlelanding/2019/cc/c9cc02849h","source_type":"PRIMARY_RESEARCH","claims_supported":["A single chiral nanoporous material containing azobenzene can change its enantioselective adsorption behavior through trans-cis photoisomerization.","The demonstrated phenylethanol behavior is strong S preference in the trans state versus approximately nonselective adsorption in the cis state, not reversal to R preference."]},{"source_id":"SRC2","title":"Control of the elution order of enantiomers by light irradiation using azobenzene-modified chiral stationary phases in micro liquid chromatography","publisher":"The Japan Society for Analytical Chemistry","url":"https://www.jstage.jst.go.jp/article/bunsekikagaku/52/10/52_10_959/_article/-char/en","source_type":"PRIMARY_RESEARCH","claims_supported":["Reversible light-controlled reversal of enantiomer elution order was demonstrated in a single microcolumn.","The column contained separate D-valine- and L-valine-derived photoresponsive stationary-phase segments; selective irradiation reduced one segment's enantioselectivity, rather than one covalent material changing between opposite recognition geometries."]},{"source_id":"SRC3","title":"Azobenzene-containing molecularly imprinted polymer microspheres with photoresponsive template binding properties","publisher":"Royal Society of Chemistry","url":"https://pubs.rsc.org/en/content/articlelanding/2011/jm/c0jm02898c","source_type":"PRIMARY_RESEARCH","claims_supported":["Azobenzene-containing molecularly imprinted polymer microspheres exhibited light-responsive template binding.","UV irradiation reduced affinity, thermal or visible-light back-isomerization restored it, and repeated switching was reported.","The template was achiral 2,4-dichlorophenoxyacetic acid, so the work does not demonstrate reciprocal enantiomer preference."]},{"source_id":"SRC4","title":"Non-Ionizing Radiation: Overview","publisher":"U.S. Occupational Safety and Health Administration","url":"https://www.osha.gov/non-ionizing-radiation","source_type":"OFFICIAL_GUIDANCE","claims_supported":["UV and excessive visible radiation can harm eyes and skin.","UV exposure can be hazardous without immediate symptoms, making enclosure and exposure controls relevant to coupon testing."]}],"problem_evidence":{"status":"PARTLY_SUPPORTED","finding":"The technical need is visible: prior work separately demonstrates chiral molecular recognition, reversible photoresponsive imprinted affinity, light-modulated enantioselective adsorption, and light-controlled reversal of elution order. The exact operational premise—a constrained batch line needing one membrane—and the asserted competitive retention or carryover from a static dual-imprint membrane were not directly documented by the retained sources.","source_ids":["SRC1","SRC2","SRC3"]},"closest_prior_art":[{"name":"Two-segment azobenzene-modified chiral microcolumn with light-controlled elution-order reversal","source_ids":["SRC2"],"overlap":"Provides one flow device, two light-responsive chiral recognition populations, wavelength-mediated selection, reversibility, and reversal of enantiomer retention order.","remaining_difference":"It uses separate opposite-valine stationary-phase segments and selectively suppresses one segment; it is not one covalent imprinted network storing and alternately exposing opposite cavity geometries."},{"name":"Photoswitchable homochiral azobenzene SURMOF","source_ids":["SRC1"],"overlap":"A single porous material uses photoisomerization to alter enantioselective adsorption remotely.","remaining_difference":"It switches from S-selective to nearly nonselective rather than reversing between S- and R-selective states, and it is not a molecularly imprinted membrane."},{"name":"Azobenzene-containing photoresponsive molecularly imprinted microspheres","source_ids":["SRC3"],"overlap":"A covalently crosslinked imprinted material reversibly changes binding affinity under UV and visible-light or thermal switching.","remaining_difference":"It gates affinity to one achiral template instead of storing opposite enantiomer-recognition maps, and it is microspherical rather than a separation membrane."}],"prior_art_disposition":"ADJACENT_PRIOR_ART","contrastive_claim_remaining":"One covalently crosslinked porous molecularly imprinted membrane—not tandem opposite stationary phases and not an enantioselective-to-nonselective gate—reproducibly reverses the sign of preference between R and S under two illumination bands, suppresses the nonselected geometry relative to a static mixed-imprint control, and restores each preregistered state after alternating cycles.","contrastive_claim_falsifier":"The claim is falsified if wavelength only changes total affinity without reversing R-versus-S preference beyond assay repeatability; both enantiomer-binding populations remain concurrently accessible; temperature-matched dark controls reproduce the effect; or either original adsorption and breakthrough profile fails to return after cycling.","gates":{"adequate_source_search":{"status":"PASS","rationale":"The bounded search covered the proposal directly, older photoresponsive-MIP and photoresponsive-stationary-phase terminology, separation practices and radiation guidance, and combinations involving enantioselectivity reversal, porous hosts, membranes, and dual templates. Four opened sources from three publishers were retained.","source_ids":["SRC1","SRC2","SRC3","SRC4"]},"supported_problem":{"status":"PASS","rationale":"The exact plant constraint and mixed-imprint carryover remain unverified, but primary research establishes the underlying separation and switching problem strongly enough for a partly supported finding.","source_ids":["SRC1","SRC2","SRC3"]},"distinct_testable_claim":{"status":"PASS","rationale":"The remaining claim is experimentally distinguishable from the closest art by requiring preference-sign reversal in one imprinted network, reciprocal suppression against a static mixed-imprint control, and state recovery after alternation.","source_ids":["SRC1","SRC2","SRC3"]},"bounded_next_test":{"status":"PASS","rationale":"Four analytical coupons, one nonhazardous racemate, two illumination bands, absorbance and temperature monitoring, adsorption and breakthrough assays, matched dark controls, and ten alternating cycles form a bounded stop-capable test. Existing studies show that the individual photochemical, imprinted-binding, and enantioselective measurements are practicable.","source_ids":["SRC1","SRC2","SRC3"]},"no_obvious_safety_or_authority_stop":{"status":"PASS","rationale":"No categorical stop is apparent for enclosed analytical-scale coupons under a materials-safety lead. UV or intense visible illumination requires shielding and eye/skin exposure controls, while heating, leaching, swelling, or integrity loss remain explicit halt conditions.","source_ids":["SRC4"]}},"screen_survival":true,"world_novelty_boundary":"This bounded four-source screen found adjacent prior art but no exact retained disclosure of the claimed single-network R/S preference reversal. It cannot establish world novelty, patentability, freedom to operate, market size, expert acceptance, scale-up feasibility, or realized separation value."}