{"schema_version":1,"experiment_id":"eoa_inverse_innovation_exp12_substrate_denial72_20260805","research_id":"eoa_inverse_innovation_exp12_light_screen_20260805","cell_id":"search_space_pruning__chemistry_materials","search_lanes":{"direct_problem_and_intervention":{"queries":["combinatorial coating library sacrificial coupon corrosion screening replica witness","high throughput corrosion resistance screening combinatorial coating libraries adhesion immersion","\"combinatorial material libraries\" corrosion immersion screening coating"],"source_ids":["SRC1","SRC3"],"no_result_note":null},"synonyms_and_historical_terms":{"queries":["combinatorial materials library destructive screening duplicate library corrosion","composition-spread thin-film library corrosion mapping delamination","high throughput materials screening sacrificial sample replicate witness coupon"],"source_ids":["SRC1","SRC2","SRC3"],"no_result_note":"No retained source used the full proposal phrase or described the complete witness-and-audit architecture; phrase misses were not treated as novelty evidence."},"products_practices_and_standards":{"queries":["ASTM coating immersion thermal cycling adhesion screening standard","combinatorial coatings library replicate coupon screening adhesion corrosion patent","high throughput coating array hydrolytic stability abrasion solvent exposure"],"source_ids":["SRC3","SRC4"],"no_result_note":null},"component_combination":{"queries":["\"coating library\" \"thermal cycling\" high throughput","combinatorial thin film library temperature adhesion delamination corrosion","combinatorial coating library staged exposure replicate audit false exclusion"],"source_ids":["SRC1","SRC2","SRC3","SRC4"],"no_result_note":"The bounded search found the component practices in close combination, but not an explicit single disclosure combining staged chemical and thermal pruning with separate unexposed-witness and exclusion-audit coupons."}},"sources":[{"source_id":"SRC1","title":"High throughput corrosion screening of Mg-Zn combinatorial material libraries","publisher":"Elsevier, Materials & Design","url":"https://www.sciencedirect.com/science/article/pii/S0264127516308280","source_type":"PRIMARY_RESEARCH","claims_supported":["Preparing and separately characterizing every alloy composition can be expensive and time-consuming.","A spatially varying Mg-Zn thin-film library was directly immersed in aqueous media and monitored optically to map corrosion rate by composition.","Direct corrosion screening of combinatorial material libraries is established prior art, including concern that accelerated destructive degradation can distort results."]},{"source_id":"SRC2","title":"Combinatorial Library Designs for Quantifying Thin Film Adhesion via the Edge Delamination Test","publisher":"National Institute of Standards and Technology","url":"https://www.nist.gov/publications/combinatorial-library-designs-quantifying-thin-film-adhesion-edge-delamination-test","source_type":"PRIMARY_RESEARCH","claims_supported":["A combinatorial coating specimen can rapidly screen adhesion across a large parameter space.","A thickness-gradient film was divided into indexed squares and exposed to an orthogonal temperature gradient to induce debonding below a critical adhesion level.","Reproducible spatial mapping of interfacial integrity and bond strength is feasible."]},{"source_id":"SRC3","title":"Method for the rapid determination of the optical quality of combinatorial libraries (US Patent 6,836,362)","publisher":"Justia Patents","url":"https://patents.justia.com/patent/6836362","source_type":"OTHER","claims_supported":["Prior art describes spatially predefined coating arrays subjected to adhesion, abrasion, solvent, fluid, hydrolytic, and other resistance tests.","It describes initial, intermediate, repeated, and in-situ screens, internal reference regions, and before-versus-after comparisons.","An example used a 48-member coating library with six replicates per formulation, and abrasion could remove coating down to the substrate."]},{"source_id":"SRC4","title":"ASTM D870-25: Standard Practice for Testing Water Resistance of Coatings Using Water Immersion","publisher":"ASTM International","url":"https://store.astm.org/standards/d870","source_type":"OFFICIAL_STANDARD","claims_supported":["Coating immersion tests are used in research and development and commonly yield pass/fail determinations based on visible failure.","Failure may reflect coating deficiency, substrate contamination, or inadequate surface preparation, supporting the need for controls and audit replicas.","Accelerated immersion results should not be equated with natural-service exposure without demonstrated correlation.","The laboratory must establish applicable safety, health, environmental, and regulatory practices."]}],"problem_evidence":{"status":"SUPPORTED","finding":"The literature directly identifies separate preparation and characterization of many compositions as expensive and time-consuming, while demonstrating corrosion and adhesion mapping on spatially indexed combinatorial libraries. Standards also recognize that immersion failures can arise from substrate contamination or preparation rather than intrinsic coating inadequacy, making false exclusion and controlled screening visible problems.","source_ids":["SRC1","SRC2","SRC4"]},"closest_prior_art":[{"name":"Optical corrosion mapping of an immersed Mg-Zn combinatorial material library","source_ids":["SRC1"],"overlap":"Direct aqueous exposure acts on a spatial composition library and rapidly distinguishes compositions by material degradation, substantially overlapping the proposal's physical environmental gate.","remaining_difference":"The study does not disclose the proposal's staged chemical-plus-thermal sequence, prespecified adhesion-retention pruning threshold, separate unexposed witness, sampled audit of exclusions, or reentry rule."},{"name":"Temperature-gradient edge-delamination screening of a combinatorial thin-film library","source_ids":["SRC2"],"overlap":"A spatial coating library is exposed to temperature-dependent stress that physically induces debonding below a critical adhesion level and maps surviving interfacial integrity.","remaining_difference":"It is an adhesion-mapping design rather than a staged corrosion-and-thermal prerequisite gate, and it does not describe witness/audit replicas or recovery of excluded regions."},{"name":"Replicated combinatorial coating arrays with iterative resistance testing","source_ids":["SRC3"],"overlap":"The patent covers indexed coating arrays, multiple replicates, before-and-after screens, repeated testing, fluid or hydrolytic exposure, adhesion/abrasion testing, internal references, and complete coating removal in severe tests.","remaining_difference":"It emphasizes optical measurement and does not clearly teach preserving a matched unexposed library for reentry while using another matched replica specifically to audit false exclusions and exposure-order or spatial artifacts."}],"prior_art_disposition":"ADJACENT_PRIOR_ART","contrastive_claim_remaining":"For an indexed coating library subject to mandatory chemical and thermal stability constraints, using three matched roles—a destructively staged gate coupon, an unexposed reentry witness, and an independently exposed exclusion-audit coupon—will reduce downstream candidates while producing a lower prespecified false-exclusion rate than a single destructive screen, without losing recoverability of excluded composition regions. The novelty-bearing contrast is the controlled witness/audit/reentry architecture, not direct exposure screening itself.","contrastive_claim_falsifier":"The contrast is falsified if matched complete-condition tests show that the staged gate's false-exclusion rate exceeds the prespecified limit, if audit replicas do not detect order or spatial artifacts, if nominally identical positions disagree beyond tolerance, if witness recipes or coordinates cannot recover excluded compositions, or if a retained source is found that already discloses the same three-replica staged gate and reentry arrangement for combinatorial coating libraries.","gates":{"adequate_source_search":{"status":"PASS","rationale":"The bounded search covered direct wording, composition-spread and high-throughput terminology, coating testing practices and standards, patents, and combinations of corrosion, thermal stress, adhesion, replication, and destructive screening. Four opened sources span three publishers plus an official research institution and an official standard.","source_ids":["SRC1","SRC2","SRC3","SRC4"]},"supported_problem":{"status":"PASS","rationale":"Primary research explicitly describes the cost and time burden of separately preparing and characterizing compositions, demonstrates direct high-throughput corrosion screening, and shows rapid adhesion mapping; ASTM identifies confounding causes of apparent immersion failure.","source_ids":["SRC1","SRC2","SRC4"]},"distinct_testable_claim":{"status":"PASS","rationale":"Although direct physical screening substantially overlaps prior art, the matched gate/witness/audit roles, isolated-stage false-negative review, and recoverable reentry rule remain a specific contrast that can be tested by error rates and replicate agreement.","source_ids":["SRC1","SRC2","SRC3"]},"bounded_next_test":{"status":"PASS","rationale":"A 36-patch matched-coupon study can prespecify thresholds, compare staged-gate classifications against isolated and complete-condition replicas, and count false exclusions, false retentions, spatial clustering, and disagreement before scaling.","source_ids":["SRC1","SRC2","SRC3","SRC4"]},"no_obvious_safety_or_authority_stop":{"status":"PASS","rationale":"A microvolume study using approved chemicals and equipment is within ordinary laboratory authority if chemical-hygiene, containment, neutralization, and waste rules are followed. ASTM assigns responsibility for safety and regulatory applicability to the user; the proposal preserves safety-authority control and supplies explicit halt conditions. No obvious categorical stop is visible, though actual reagents and temperatures require local approval.","source_ids":["SRC4"]}},"screen_survival":true,"world_novelty_boundary":"This light, bounded public-web search establishes neither world novelty nor patentability. It cannot establish market size, expert acceptance, realized value, freedom to operate, or the completeness of patent and non-English literature. Direct physical screening of combinatorial coating libraries is established; only the narrower staged three-replica audit-and-reentry contrast remains after this screen."}