{"closest_prior_art":[{"name":"Choi et al. 2017 chrono-sampling sweat patch","overlap":"A skin-mounted passive microfluidic network uses differential capillary-bursting valves to route sweat sequentially into separate fixed-volume reservoirs for storage, retrieval, and ex situ biochemical analysis; human trials recovered temporal lactate, sodium, and potassium variation.","remaining_difference":"It retains liquid in PDMS chambers rather than discharging a refreshed fast reservoir into removable sorbent lanes with drying, chelation, preservative chemistry, flow-witness reconciliation, and lane-mass checks.","source_ids":["SRC1"]},{"name":"Abbasiasl et al. 2022 paper-integrated sequential sweat device","overlap":"A sealed wearable device uses filter paper's capillary force to route sweat sequentially into paper-containing chambers, limits evaporation by eliminating individual air exits, and incorporates dry colorimetric chemistry.","remaining_difference":"It performs in situ colorimetric analysis and does not disclose the proposed two-store discharge architecture, removable dried-specimen archive for later multi-analyte laboratory assay, or paired witness and mass-integrity checks.","source_ids":["SRC2"]},{"name":"Steijlen et al. 2022 chronological collector for offline analysis","overlap":"A continuously renewed upstream analysis chamber feeds a sequence of consecutively filling reservoirs whose specimens are later extracted and analyzed by laboratory ion chromatography; the method reduces repetitive handling and contamination relative to absorbent patches.","remaining_difference":"The downstream stores remain liquid and require manual extraction, dilution, freezing, and vials; there is no burst-triggered transfer into stabilized dried lanes, removable archive strip, or passive physical reconciliation witness.","source_ids":["SRC3"]}],"contrastive_claim_falsifier":"The remaining contrast is falsified if a direct pre-existing system is shown to combine a rapidly refreshed upstream liquid reservoir, passive fixed-volume discharge into successive indexed sorbent lanes, analyte-appropriate dry stabilization and drying for delayed laboratory assay, and physical transfer-integrity reconciliation—or if the proposed bench prototype cannot meet its preregistered order, carryover, skipped-lane, and 24-hour recovery limits.","contrastive_claim_remaining":"A narrow, testable integration remains: each fixed-volume aliquot leaves a rapidly refreshed liquid reservoir and is passively committed to the next removable sorbent lane, where drying and analyte-specific preservation create an ordered laboratory specimen archive whose transfers are reconciled by an inert witness and lane-mass checks. The broader concepts of passive sequential sweat sampling, paper-filled reservoirs, upstream renewal, and offline analysis are already demonstrated.","experiment_id":"eoa_inverse_innovation_exp13_second_slot_policy60_20260806","gates":{"adequate_source_search":{"rationale":"Direct intervention, chrono-sampling terminology, paper/sorbent component combinations, offline-analysis practices, and a recognized sweat-collection standard were searched. Exactly four opened direct sources span Wiley-VCH, the Royal Society of Chemistry, the American Chemical Society/PMC, and FDA/CLSI.","source_ids":["SRC1","SRC2","SRC3","SRC4"],"status":"PASS"},"bounded_next_test":{"rationale":"The authorized artificial-sweat pulse study is bounded and can measure lane order, fill volume, carryover, leakage, skipped-lane detection, witness accuracy, and 24-hour recovery against sealed aliquots and a pooled patch. It does not require human attachment or clinical/training decisions.","source_ids":["SRC1","SRC2","SRC3"],"status":"PASS"},"distinct_testable_claim":{"rationale":"Although the broad architecture substantially overlaps prior work, the combined fast-reservoir-to-removable-dried-lane transfer, chemical stabilization, and physical reconciliation claim has explicit observable outputs and quantitative falsifiers.","source_ids":["SRC1","SRC2","SRC3"],"status":"PASS"},"no_obvious_safety_or_authority_stop":{"rationale":"A fixture-only artificial-sweat test avoids skin-contact and athlete-decision risks. FDA recognition of CLSI C34 confirms that validated specimen collection, QA, and qualified laboratory interpretation matter if the work later enters clinical use; the stated exclusions preserve those boundaries.","source_ids":["SRC4"],"status":"PASS"},"supported_problem":{"rationale":"Primary studies explicitly identify limitations of pooled or repeatedly replaced absorbent collectors, demonstrate temporal sweat-composition variation, and document evaporation or contamination concerns. They also show that chronological collection and delayed laboratory analysis are active technical needs.","source_ids":["SRC1","SRC2","SRC3"],"status":"PASS"}},"prior_art_disposition":"SUBSTANTIAL_COLLISION","problem_evidence":{"finding":"The problem is visible: conventional absorbent sampling is labor-intensive and temporally coarse; sequentially isolated samples reveal within-exercise variation; and liquid microreservoirs can suffer material evaporation, while paper-integrated designs explicitly seek to reduce evaporation. Evidence supports the collection and preservation problem, though it does not establish that every intended biomarker needs the proposed stabilizer chemistry.","source_ids":["SRC1","SRC2","SRC3"],"status":"SUPPORTED"},"research_id":"eoa_inverse_innovation_exp13_light_screen_20260806","schema_version":1,"screen_id":"E13P028","screen_survival":false,"search_lanes":{"component_combination":{"no_result_note":null,"queries":["sweat patch chronological sampling discrete reservoirs colorimetric microfluidic sequential","sweat sampling patch dried spot preservative stabilization sorbent","dried sweat spot sampling analyte stability preservative chelator wearable patch laboratory analysis","wearable paper-integrated microfluidic device sequential analysis sweat capillary action"],"source_ids":["SRC1","SRC2","SRC3"]},"direct_problem_and_intervention":{"no_result_note":null,"queries":["wearable sweat patch sequential sampling reservoirs capillary burst valves time-resolved sweat collection","wearable sweat collector time-resolved samples stored for later laboratory analysis","sequential sweat collection offline laboratory analysis separate reservoirs capillary patch"],"source_ids":["SRC1","SRC2","SRC3"]},"products_practices_and_standards":{"no_result_note":null,"queries":["sweat collection storage guidelines evaporation contamination analyte stability official","sweat sample stability evaporation storage biochemical analysis delayed analysis study","sweat collection filter paper gauze commercial coiled tubing CLSI C34"],"source_ids":["SRC1","SRC3","SRC4"]},"synonyms_and_historical_terms":{"no_result_note":null,"queries":["chrono-sampling sweat capillary bursting valves ex situ analysis","chronological sampling sweat offline analysis separate microreservoirs","paper-integrated chrono-analysis sweat capillary action"],"source_ids":["SRC1","SRC2","SRC3"]}},"sources":[{"claims_supported":["Passive differential capillary-bursting valves sequentially fill discrete sweat reservoirs.","The device supports specimen retrieval and ex situ analysis of temporal lactate, sodium, and potassium variation.","The paper reports evaporation of about 10% of chamber volume per hour under one tested condition and discusses long-term storage controls."],"publisher":"Wiley-VCH; full text hosted by Northwestern University","source_id":"SRC1","source_type":"PRIMARY_RESEARCH","title":"Thin, Soft, Skin-Mounted Microfluidic Networks with Capillary Bursting Valves for Chrono-Sampling of Sweat","url":"https://bioelectronics.northwestern.edu/documents/advhmufl.pdf"},{"claims_supported":["A wearable paper-integrated microfluidic device routes artificial sweat sequentially by capillary action.","Embedded filter paper and encapsulation support sequential chemical analysis.","Eliminating separate reservoir air exits is presented as a way to reduce evaporation."],"publisher":"Royal Society of Chemistry","source_id":"SRC2","source_type":"PRIMARY_RESEARCH","title":"A wearable paper-integrated microfluidic device for sequential analysis of sweat based on capillary action","url":"https://pubs.rsc.org/en/Content/ArticleLanding/2022/SD/D2SD00032F"},{"claims_supported":["A continuously renewed upstream chamber feeds consecutively filling sweat reservoirs.","Sequential reservoir specimens are extracted for offline laboratory ion chromatography.","Chronological sampling reduces repetitive labor and contamination exposure compared with absorbent-patch workflows."],"publisher":"American Chemical Society","source_id":"SRC3","source_type":"PRIMARY_RESEARCH","title":"Low-Cost Wearable Fluidic Sweat Collection Patch for Continuous Analyte Monitoring and Offline Analysis","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9096792/"},{"claims_supported":["FDA recognizes CLSI C34 4th Edition for sweat-specimen collection and quantitative chloride analysis.","The standard covers collection using filter paper, gauze, or a commercial coiled-tubing collector and addresses validation, QA, and analytical and biological error sources.","Clinical sweat-test interpretation is assigned to qualified laboratory and clinical personnel."],"publisher":"U.S. Food and Drug Administration / Clinical and Laboratory Standards Institute","source_id":"SRC4","source_type":"OFFICIAL_STANDARD","title":"Recognized Consensus Standards: CLSI C34 4th Edition, Sweat Testing: Specimen Collection and Quantitative Chloride Analysis","url":"https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfstandards/detail.cfm?standard__identification_no=41571"}],"world_novelty_boundary":"This bounded public-web screen found substantial collision with the proposal's broad architecture but did not locate the complete narrowed integration in one retained source. It cannot establish world novelty, patentability, freedom to operate, obviousness, market size, expert acceptance, realized value, or absence of unindexed, non-English, proprietary, or unpublished prior art."}