{"closest_prior_art":[{"name":"Timestrip PLUS cumulative time-temperature indicator","overlap":"A serialized, manually activated, irreversible, single-use, nonpowered indicator uses dye migration through a porous membrane to display cumulative exposure as a visible progress distance; it is marketed for package-level clinical-sample transport without software or a reader.","remaining_difference":"The product is not disclosed as being serially assigned to mechanically sealed forensic-evidence custody intervals or validated for evidentiary packaging, reader agreement, contamination, and legal contestability.","source_ids":["SRC3"]},{"name":"Evergreen tamper-evident forensic/specimen accessories","overlap":"The product family places adhesive temperature strips and uniquely identified tamper-evident locks within chain-of-custody, forensic-sample, and biological-specimen transport applications.","remaining_difference":"Its listed temperature strips are liquid-crystal indicators rather than irreversible cumulative reaction-front witnesses, and the page does not define activation-to-seal-break interval assignment.","source_ids":["SRC4"]},{"name":"WHO Blood Time Temperature Indicator practice","overlap":"WHO describes an analogous between-stage preservation problem and an activated chemical-migration indicator whose irreversible visible progression integrates successive elevated-temperature exposures during blood transport.","remaining_difference":"The practice concerns transfusion inventory and consignments, not case evidence, serial forensic seals, resealing boundaries, or evidentiary review.","source_ids":["SRC2"]},{"name":"NIST biological-evidence packaging and preservation guidance","overlap":"NIST requires temperature-appropriate preservation, tamper-evident package sealing, dated seal markings, unique identifiers, and documentation of packaging and custody events.","remaining_difference":"The guidance does not disclose a passive cumulative package-level exposure indicator assigned separately to each sealed interval.","source_ids":["SRC1"]}],"contrastive_claim_falsifier":"The remaining contrast would be falsified by a documented forensic product or validated laboratory procedure that already assigns a serialized, activated, irreversible cumulative time-temperature progress strip to each mechanically delimited evidence-package interval and preserves the strip reading as a contestable custody observation. It would also fail empirically if the proposed strip cannot outperform spot indicators and event logs on controlled hidden excursions while meeting prespecified repeatability, compatibility, activation, seal-boundary, and contamination limits.","contrastive_claim_remaining":"A narrow, testable contrast remains: adapt the already-established cumulative visible time-temperature indicator mechanism to forensic governance by serially binding each indicator to one activation-to-seal-break interval, then validate both its continuous exposure reading and its discrete seal boundaries for mock evidence packages. The passive indicator technology itself is not contrastively new.","experiment_id":"eoa_inverse_innovation_exp13_second_slot_policy60_20260806","gates":{"adequate_source_search":{"rationale":"Four search lanes covered the proposal directly, older time-temperature-indicator terminology, forensic and specimen products, official preservation guidance, and combinations of temperature strips with tamper-evident custody packaging. Four opened direct sources span NIST, WHO, Timestrip, and Evergreen.","source_ids":["SRC1","SRC2","SRC3","SRC4"],"status":"PASS"},"bounded_next_test":{"rationale":"The proposed 60-pouch environmental-chamber study is finite, uses mock packages and nonhazardous surrogates, includes reference loggers, multiple lots, controlled boundary cases, blinded readers, and prespecified failure observations. It stops before live-evidence use.","source_ids":["SRC1","SRC3","SRC4"],"status":"PASS"},"distinct_testable_claim":{"rationale":"Although the indicator mechanism and adjacent forensic accessories already exist, the narrower interval-binding claim can be tested by comparing serialized activation-to-seal-break assignments and cumulative readings against hidden reference profiles and ordinary spot/event records.","source_ids":["SRC1","SRC3","SRC4"],"status":"PASS"},"no_obvious_safety_or_authority_stop":{"rationale":"A mock-only chamber study does not require evidentiary rulings or alteration of live evidence. Package compatibility, leakage, activation failure, contamination, saturation, and reader disagreement are explicit stop criteria; any later operational or legal use remains subject to laboratory policy and authorized personnel.","source_ids":["SRC1","SRC3"],"status":"PASS"},"supported_problem":{"rationale":"NIST confirms that biological evidence requires controlled temperatures, protection from degradation, sealed packaging, and event-oriented custody documentation. WHO independently identifies an undefined risk from cumulative or single temperature exposure during multi-stage handling. The exact prevalence of this unmeasured gap in forensic evidence rooms was not established, so support is partial rather than complete.","source_ids":["SRC1","SRC2"],"status":"PASS"}},"prior_art_disposition":"SUBSTANTIAL_COLLISION","problem_evidence":{"finding":"The preservation concern is visible: temperature-sensitive biological material can degrade, temporary transport and storage locations require different controls, and cumulative exposure across handling stages can remain consequential despite ordinary quality procedures. However, the retained evidence demonstrates the between-event measurement gap directly for blood cold-chain practice and only inferentially for forensic evidence packages.","source_ids":["SRC1","SRC2"],"status":"PARTLY_SUPPORTED"},"research_id":"eoa_inverse_innovation_exp13_light_screen_20260806","schema_version":1,"screen_id":"E13P138","screen_survival":false,"search_lanes":{"component_combination":{"no_result_note":null,"queries":["forensic specimen kit temperature indicator tamper evident seal chain of custody product","drug testing specimen transport temperature indicator strip chain custody tamper evident","tamper evident seals time temperature indicator specimen transport standard"],"source_ids":["SRC1","SRC3","SRC4"]},"direct_problem_and_intervention":{"no_result_note":null,"queries":["forensic evidence temperature monitoring chain of custody biological evidence refrigeration guidance","time temperature indicator forensic evidence package chain of custody","evidence bag time temperature indicator forensic"],"source_ids":["SRC1","SRC3","SRC4"]},"products_practices_and_standards":{"no_result_note":null,"queries":["passive chemical time temperature indicator diffusion reaction front product irreversible","forensic specimen kit temperature indicator tamper evident seal chain of custody product","blood evidence transport time temperature indicator chain of custody"],"source_ids":["SRC1","SRC2","SRC3","SRC4"]},"synonyms_and_historical_terms":{"no_result_note":null,"queries":["site:who.int \"Blood time temperature indicator\" cumulative exposure","site:who.int blood cold chain time temperature indicator migration chemical paper wick","drug testing specimen transport temperature indicator strip chain custody tamper evident"],"source_ids":["SRC2","SRC3","SRC4"]}},"sources":[{"claims_supported":["Biological evidence must be protected from degradation and excessive heat, with specified refrigerated and controlled-temperature conditions.","Evidence packages should visibly reveal opening, carry unique identifiers and dated seal markings, and preserve packaging and custody documentation.","Temporary storage and transport occur across medical facilities, property rooms, and vehicles."],"publisher":"National Institute of Standards and Technology / National Institute of Justice Technical Working Group","source_id":"SRC1","source_type":"OFFICIAL_GUIDANCE","title":"The Biological Evidence Preservation Handbook: Best Practices for Evidence Handlers (NIST IR 7928)","url":"https://www.nist.gov/system/files/documents/forensics/NIST-IR-7928.pdf"},{"claims_supported":["Blood may experience varying or unknown temperature periods across processing and transportation despite equipment monitoring and procedures.","The Blood Time Temperature Indicator uses activated chemical migration through a paper wick and irreversible visible progression to represent cumulative exposure.","The indicator supplements rather than replaces existing quality-assurance measures."],"publisher":"World Health Organization","source_id":"SRC2","source_type":"OFFICIAL_GUIDANCE","title":"The Blood Cold Chain: Guide to the Selection and Procurement of Equipment and Accessories","url":"https://www.who.int/publications/i/item/9241545798"},{"claims_supported":["Timestrip PLUS is a serialized, manually activated, irreversible, single-use, nonpowered time-temperature indicator.","Dye migration produces a continuous visible progress distance representing cumulative time above a threshold across repeated excursions.","The product is offered for package-level clinical-sample transport and requires no software or electronic reader."],"publisher":"Timestrip UK Ltd.","source_id":"SRC3","source_type":"FIRST_PARTY_PRODUCT","title":"Timestrip PLUS","url":"https://timestrip.com/indicator-labels/temperature-indicators/timestrip-plus"},{"claims_supported":["Commercial accessories already combine the neighboring functions of temperature indication and uniquely identified tamper-evident locks.","The stated applications include drug-testing chain of custody, forensic-sample integrity, and sensitive or infectious specimen transport.","The listed temperature indicator is adhesive-backed liquid crystal rather than a cumulative irreversible migration strip."],"publisher":"Caplugs / Evergreen Scientific","source_id":"SRC4","source_type":"FIRST_PARTY_PRODUCT","title":"Tamper Evident Kits & Accessories","url":"https://www.evergreensci.com/p/tamper-evident-accessories"}],"world_novelty_boundary":"This bounded public-web screen found a substantial collision in the core passive cumulative indicator and adjacent forensic custody packaging components. It did not locate a direct disclosure of the narrower per-sealed-interval forensic validation rule, but that absence cannot establish world novelty, patentability, market size, expert acceptance, realized value, or freedom to operate."}