{"closest_prior_art":[{"name":"Individualized intermittent hypoxic exposure for elite athletes","overlap":"A medically supervised preliminary test measured time for SpO2 to fall to 85% at FiO2 0.12 and return to 95% in normoxia; those response and recovery times individualized repeated 3–8-minute hypoxic bouts, 3–5-minute normoxic intervals, and later oxygen reduction while SpO2 and heart rate were monitored.","remaining_difference":"It did not test several conservative FiO2 plateaus with matched submaximal work, independent interface-gas verification, coordination and sleep outcomes, reviewer-agreed regime classifications, or whether those classifications improve acclimatization-tempo decisions beyond simple fall-and-recovery timing.","source_ids":["SRC3"]},{"name":"Five-phase hypoxic exercise test and severe-high-altitude-illness decision score","overlap":"The reviewed clinical protocol already uses medical consultation followed by normoxic rest, hypoxic rest, hypoxic exercise, and normoxic exercise, measuring SpO2, ventilation, and ECG to characterize individual hypoxic response and support a risk decision.","remaining_difference":"It uses essentially one hypoxic level and does not estimate a multi-plateau threshold range, analyze entry-versus-return hysteresis, follow delayed sleep or recovery, or adapt a training transition from reproducible regime classifications.","source_ids":["SRC2"]},{"name":"Hypoxia conditioning and pre-acclimatization practice","overlap":"Published practice includes progressive or tolerance-adjusted simulated altitude, repeated hypoxia separated by normoxia, submaximal performance assessment, and longitudinal monitoring of SpO2, heart rate, blood pressure, symptoms, sleep, and individual tolerability; official guidance also recognizes staged ascent, pre-acclimatization, and commercial hypoxic systems.","remaining_difference":"No retained source specifies the complete preregistered within-athlete assay combining independently verified plateaus, paired returns, multi-resolution change-point analysis, rival-artifact adjudication, and a comparison against fixed-schedule decisions.","source_ids":["SRC1","SRC4"]}],"contrastive_claim_falsifier":"The remaining claim is falsified if replicated verified plateaus yield low reviewer agreement or unstable regime labels, entry and return trajectories are effectively symmetric, delayed outcomes add no information, or hold/regress/abandon decisions are no better than decisions from FiO2 dose, elapsed exposure, and simple SpO2 fall-and-recovery times.","contrastive_claim_remaining":"Among medically screened endurance athletes, a preregistered series of several independently verified conservative FiO2 plateaus, matched submaximal tasks, and paired normoxic returns will produce reproducible change-point and entry-return-asymmetry classifications that add decision-relevant information about next-day recovery and transition tempo beyond verified oxygen dose, elapsed time, and simple SpO2 fall-and-recovery timing.","experiment_id":"eoa_inverse_innovation_exp13_second_slot_policy60_20260806","gates":{"adequate_source_search":{"rationale":"The bounded search covered the proposal directly, hypoxic-effort and intermittent-conditioning terminology, staged-ascent guidance and commercial practices, chamber safety concepts, and combinations of graded exposure, exercise, reoxygenation, and individualized monitoring. Exactly four opened sources from four publication venues were retained, including primary research and professional guidance.","source_ids":["SRC1","SRC2","SRC3","SRC4"],"status":"PASS"},"bounded_next_test":{"rationale":"An equipment-only validation followed, only after ethics and medical approval, by no more than eight screened adults, three conservative plateaus, submaximal work, predefined stopping rules, and endpoints limited to feasibility, repeatability, agreement, and asymmetry is bounded and directly tests the remaining claim. Existing clinical testing and medically supervised intermittent exposure demonstrate feasibility, without validating competition readiness.","source_ids":["SRC2","SRC3"],"status":"PASS"},"distinct_testable_claim":{"rationale":"The broad idea of individualized reversible hypoxia is substantially prefigured, but the narrower incremental-value claim—reproducible multi-plateau change-point and return-path classifications improving decisions over simple dose, time, and SpO2-response measures—is distinct and falsifiable.","source_ids":["SRC2","SRC3","SRC4"],"status":"PASS"},"no_obvious_safety_or_authority_stop":{"rationale":"The authorized first step exposes no athlete. The proposed human feasibility work requires medical and ethics approval, physician eligibility and stopping authority, independent gas verification, rapid normoxia restoration, and unconditional athlete stop rights. These controls align with guidance emphasizing graded exposure, descent or oxygen for serious illness, medical monitoring, and caution about simulated-altitude limitations; residual risk requires oversight but is not an obvious categorical stop.","source_ids":["SRC1","SRC3","SRC4"],"status":"PASS"},"supported_problem":{"rationale":"Sources show wide individual variation, conflicting predictive value of resting SpO2, delayed altitude illness, heterogeneous pre-acclimatization results, protocol-dependent outcomes, and imperfect equivalence between normobaric and terrestrial or hypobaric altitude. Direct evidence that conservative plateaus commonly produce sharp thresholds or hysteresis is limited, so support is partial rather than complete.","source_ids":["SRC1","SRC2","SRC3","SRC4"],"status":"PASS"}},"prior_art_disposition":"SUBSTANTIAL_COLLISION","problem_evidence":{"finding":"The practical problem is visible: individual hypoxic tolerance and acclimatization vary, simple resting measures can conflict, illness may emerge hours after exposure, and simulated-altitude protocols have mixed results and limited transfer to real altitude. However, the retained literature does not directly establish that multiple conservative FiO2 steps routinely reveal discontinuities, persistent reorganization, or decision-relevant entry-return hysteresis.","source_ids":["SRC1","SRC2","SRC3","SRC4"],"status":"PARTLY_SUPPORTED"},"research_id":"eoa_inverse_innovation_exp13_light_screen_20260806","schema_version":1,"screen_id":"E13P179","screen_survival":false,"search_lanes":{"component_combination":{"no_result_note":null,"queries":["graded stepwise normobaric hypoxia test athletes oxygen plateaus recovery normoxia protocol","progressive hypoxia reoxygenation hysteresis ventilatory response test athletes","intermittent hypoxic training alternating hypoxia normoxia athlete individualized protocol oxygen saturation"],"source_ids":["SRC2","SRC3","SRC4"]},"direct_problem_and_intervention":{"no_result_note":null,"queries":["graded stepwise normobaric hypoxia test athletes oxygen plateaus recovery normoxia protocol","hypoxic exercise test athlete altitude illness susceptibility normobaric protocol medical screening SpO2 ventilation heart rate","progressive hypoxia reoxygenation hysteresis ventilatory response test athletes"],"source_ids":["SRC2","SRC3"]},"products_practices_and_standards":{"no_result_note":null,"queries":["altitude acclimatization guidelines staged ascent hypoxic preacclimatization athletes competition","commercial hypoxic training system independent oxygen analyzer alarm emergency normoxia chamber standard","normobaric hypoxic chamber safety standard oxygen monitoring alarm carbon dioxide ventilation"],"source_ids":["SRC1","SRC3","SRC4"]},"synonyms_and_historical_terms":{"no_result_note":null,"queries":["intermittent hypoxic training alternating hypoxia normoxia athlete individualized protocol oxygen saturation","hypoxic effort test high-altitude pathology normobaric exercise","Intermittent Hypoxic Exposure GO2Altitude athletes medical supervision"],"source_ids":["SRC2","SRC3","SRC4"]}},"sources":[{"claims_supported":["Staged ascent and pre-acclimatization are recognized preventive practices, but studies of repeated normobaric or hypobaric exposure have mixed results and no single optimal protocol is endorsed.","Short exposures are less likely to produce acclimatization, and commercial hypoxic systems lack evidence of improved summit success or physical performance.","Altitude illness can be delayed; severe neurological or pulmonary illness warrants descent or oxygen, and pulse oximetry has contextual limitations."],"publisher":"Wilderness Medical Society / Wilderness & Environmental Medicine","source_id":"SRC1","source_type":"OFFICIAL_GUIDANCE","title":"Wilderness Medical Society Clinical Practice Guidelines for the Prevention, Diagnosis, and Treatment of Acute Altitude Illness: 2024 Update","url":"https://journals.sagepub.com/doi/full/10.1016/j.wem.2023.05.013"},{"claims_supported":["Individual susceptibility to altitude illness varies widely, resting SpO2 findings conflict, and easy prediction remains unavailable.","A clinical hypoxic exercise test already sequences normoxic rest, hypoxic rest, hypoxic exercise, and normoxic exercise while measuring SpO2, ventilation, and ECG.","Hypoxic-exercise variables can improve risk discrimination, but evidence comes largely from one research group and needs independent confirmation."],"publisher":"MDPI","source_id":"SRC2","source_type":"SECONDARY_RESEARCH","title":"Contribution of Hypoxic Exercise Testing to Predict High-Altitude Pathology: A Systematic Review","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8950822/"},{"claims_supported":["Elite athletes underwent medical evaluation and ethics-approved, medically supervised intermittent hypoxic exposure.","A preliminary FiO2 0.12 test measured time to SpO2 85% and time to recover to 95% in normoxia, and results individualized the exposure protocol.","The protocol used repeated hypoxic and normoxic intervals, progressive oxygen reduction, and session-level SpO2 and heart-rate monitoring."],"publisher":"BioMed Research International (Wiley/Hindawi)","source_id":"SRC3","source_type":"PRIMARY_RESEARCH","title":"Intermittent Hypoxic Exposure Reduces Endothelial Dysfunction","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7453230/"},{"claims_supported":["Intermittent hypoxia conditioning commonly alternates 3–8-minute hypoxic bouts with 2–5-minute normoxic or hyperoxic periods and monitors SpO2 and heart rate.","Progressive or tolerance-adjusted simulated altitude, submaximal performance, symptoms, sleep, blood pressure, and individual monitoring are established pre-acclimatization concepts.","Normobaric and hypobaric exposures can differ, evidence remains heterogeneous, and robust safety-conscious evaluations are still needed."],"publisher":"Springer Nature","source_id":"SRC4","source_type":"SECONDARY_RESEARCH","title":"Hypoxia Conditioning for High-Altitude Pre-acclimatization","url":"https://link.springer.com/article/10.1007/s42978-021-00150-0"}],"world_novelty_boundary":"This four-source public-web screen identifies substantial collision with individualized hypoxic testing and intermittent hypoxia-normoxia conditioning. It does not establish world novelty, patentability, freedom to operate, market size, expert acceptance, clinical utility, competition transfer, or realized value; it is not an exhaustive patent, non-English, product-manual, standards, or unpublished-protocol search."}