{"abstention_reason":null,"arm":"SUBSTRATE_DIVERSE_P2","candidate_id":"fast_slow_store_coupling__sport_science__SUBSTRATE_DIVERSE_P2","cell_id":"fast_slow_store_coupling__sport_science","decision":"PROPOSAL","experiment_id":"eoa_inverse_innovation_exp13_second_slot_policy60_20260806","proposal":{"actors":["Athlete","Exercise physiologist","Analytical chemist","Sampling-equipment technician"],"affected_objective":"Preserve interval-resolved sweat specimens for delayed biochemical analysis without allowing newly secreted sweat to mix, evaporate, or chemically degrade before stabilization.","arm":"SUBSTRATE_DIVERSE_P2","authority_safety":{"authorized_first_step":"Bench-test prototype patches with coded artificial-sweat pulse trains on a heated, moving synthetic-skin fixture; do not attach prototypes to people or use results for training, medical, hydration, or eligibility decisions.","decision_authority":"The analytical chemist determines specimen validity; qualified medical and coaching personnel retain all authority over athlete care and training, and prototype measurements have no decision authority.","excluded_actions":["Applying an unvalidated prototype to an athlete","Using patch results to diagnose illness, prescribe hydration, change training load, determine return-to-play status, or assess competition eligibility","Collecting or assaying prohibited or unrelated biomarkers","Reusing skin-contact components or opening loaded sorbent cassettes outside the designated laboratory","Representing sequential lane position as clock time without an independently verified sweat-flow reference"],"halt_rollback":"Halt testing if liquid bypasses the containment layer, adjacent archive lanes show cross-contamination, stabilizer migrates toward the skin-facing inlet, lane order becomes ambiguous, or coded samples cannot be reconciled. Quarantine and discard affected single-use cassettes under laboratory procedures, clean the fixture, and revert to sealed-vial reference sampling."},"baseline":"A conventional absorbent sweat patch pools secretion collected across much of a training bout, or staff interrupt exercise to transfer occasional samples into labeled vials. Pooling erases within-bout variation, while manual aliquoting is slow, contamination-prone, and difficult during movement; unstabilized samples may also evaporate or continue reacting before laboratory processing.","candidate_id":"fast_slow_store_coupling__sport_science__SUBSTRATE_DIVERSE_P2","causal_chain":["Newly secreted sweat enters a skin-adjacent, low-dead-volume microreservoir quickly enough to limit mixing with earlier secretion.","A fixed fill volume raises capillary pressure to the burst threshold of the next passive valve.","The valve transfers that discrete aliquot from the fast reservoir into the corresponding indexed sorbent lane before the reservoir accepts the next aliquot.","Dry chelator and preservative chemistry in the sorbent binds or stabilizes target analytes, while a vapor-permeable barrier removes water and converts the liquid aliquot into a durable dried spot.","Sequential passive valves route later aliquots to later lanes, creating an ordered physical archive rather than one pooled specimen.","A paired inert-dye flow witness and lane mass check expose incomplete transfer, backflow, lane skipping, and cross-lane carryover before biochemical interpretation.","After the bout, the sealed strip is removed and assayed in the laboratory; only lanes passing physical integrity and calibration checks contribute to the reconstructed within-bout profile."],"cell_id":"fast_slow_store_coupling__sport_science","consequence":"Short-lived biochemical changes within a training bout are averaged away or altered before assay, preventing researchers from distinguishing genuine interval-level responses from pooled-sample artifacts.","diversity_from_prior_proposals":"P1 concerns the informational transfer of human coaching observations into a longitudinal athlete ledger. This proposal instead addresses loss of time-resolved biological specimens and uses passive capillary mechanics, sorbent materials, drying, and stabilizing chemistry to transfer sweat from a rapidly filling liquid reservoir into a durable physical archive. Its problem, intervention, and causal path do not depend on P1's scratchpad, staff review, terminology normalization, sensor-record linkage, or record reconciliation.","experiment_id":"eoa_inverse_innovation_exp13_second_slot_policy60_20260806","intervention":"Develop a single-use, skin-adjacent sweat sampler containing two materially distinct stores. The fast store is a low-dead-volume microfluidic reservoir that rapidly accepts newly secreted sweat during movement. At a fixed fill volume, passive capillary burst valves discharge successive aliquots into separate indexed lanes of a removable slow-store strip. Each lane contains dry sorbent, chelator, and analyte-appropriate preservative beneath a vapor-permeable containment membrane, so transfer both isolates the aliquot and stabilizes it as a dried spot. A nonreactive flow-witness track and post-collection lane-mass check identify incomplete transfer, backflow, or skipped lanes. The sealed strip is later analyzed in a laboratory; no software or automated control is required for capture, transfer, stabilization, ordering, or retention.","mechanism_mapping":[{"counterfactual_removal":"Without the fast-to-slow discharge path, the reservoir would merely pool incoming sweat until mixing, overflow, or evaporation destroyed interval resolution.","mechanism_slug":"write_back_cache_with_durable_backing_store","role":"A rapidly filling liquid microreservoir accepts provisional aliquots, then passively discharges each into a chemically stabilized sorbent archive lane."},{"counterfactual_removal":"Without sorption, drying, and preservative chemistry during transfer, lane separation alone would not prevent continued reaction, evaporation bias, or analyte loss before laboratory assay.","mechanism_slug":"short_term_to_long_term_memory_consolidation_routine","role":"The consolidation transform converts fragile liquid sweat into isolated, durable dried specimens while retaining collection order."},{"counterfactual_removal":"Without indexed sequential lanes and physical integrity witnesses, partial transfers or backflow could silently produce an incoherent specimen history.","mechanism_slug":"commit_log_and_compaction_cycle","role":"Successive aliquots occupy append-only physical lanes, while witness tracks and mass checks reconcile transfer order and specimen integrity before assay."}],"nearest_rivals":["A conventional absorbent sweat patch that creates one durable pooled sample but cannot preserve interval order","Repeated manual pipette or vial collection, which can preserve aliquots but interrupts activity and lacks an automatically coupled fast capture layer","A real-time electrochemical sweat sensor, which estimates selected analytes immediately but does not retain durable specimens for later multi-analyte validation","A refrigerated bulk-sweat vial, which slows degradation but retains neither rapid skin-level capture nor sequential separation"],"negative_tests":{"intervention_falsifier":"The intervention is falsified in the coded bench test if sequential lanes cannot recover the imposed concentration order, if adjacent-lane carryover exceeds the pre-registered 5% limit, if any lane is skipped without detection, or if 24-hour stabilized-sample recovery differs by more than 10% from immediately sealed reference aliquots for the target analytes.","problem_falsifier":"The problem is unsupported if representative pulse trains and reference samples show that within-bout concentration variation is no larger than analytical and flow-rate uncertainty, or that an ordinary pooled patch preserves every measurement needed for the intended sport-science analysis.","risks":["Skin-contact materials could cause irritation in a later human study.","Exercise motion or variable sweat rate could cause leakage, backflow, incomplete filling, or misleading lane duration.","Preservatives or adhesives could contaminate target analytes.","Differential drying could bias concentration estimates.","Lane position could be mistaken for elapsed time when sweat flow changes.","The archive could enable collection of sensitive biomarkers beyond the consented purpose.","Added fluidic resistance could alter local sweat accumulation and sample composition."],"strongest_counterevidence":"If blinded artificial-sweat and ex vivo comparisons show substantial cross-lane mixing or analyte-dependent stabilization bias, the physical archive would manufacture apparent interval changes rather than preserve them."},"next_evidence_step":"Fabricate a small passive prototype and run a blinded bench study using artificial sweat delivered as alternating coded concentration pulses across several flow rates on a heated fixture with programmed motion. Compare recovered lane order, fill volume, carryover, leakage, 24-hour analyte recovery, skipped-lane detection, and flow-witness accuracy against immediately sealed reference aliquots and a pooled absorbent patch.","observable_state":"During collection, sweat occupies only the current transparent microreservoir while previously transferred aliquots appear as separated wetted positions on a numbered sorbent strip behind a containment membrane. After drying, the removable strip contains ordered discrete spots plus a parallel flow-witness trace; inspection records lane mass, transfer completeness, backflow evidence, skipped lanes, seal integrity, and assay-validity status.","prior_art_status":"UNSEARCHED","problem":"Sweat composition can change across warm-up, work, recovery, and repeated high-intensity intervals, but common patches pool secretion over time. Newly secreted liquid must be captured with little delay to preserve interval separation, whereas reliable later assay requires isolation, chemical stabilization, contamination control, and durable retention. A single pooled absorbent layer cannot optimize both rapid local capture and an ordered, stable specimen archive.","proposal_index":2,"remaining_contrastive_claim":"The essential innovation is a passive physical transfer from a rapidly refreshed liquid capture reservoir into sequential chemically stabilized archive lanes; it is neither an athlete-record workflow nor a real-time computational sensor.","revision_record":{"claim_changes":[],"conceptual_changes":["Selected biological specimen preservation rather than observational record consolidation as the independent opportunity.","Realized both stores and their coupling through microfluidics, sorbent materials, and stabilization chemistry."],"evidence_changes":[],"operational_changes":["Restricted the first step to coded artificial-sweat bench testing with no human exposure or athlete-management use."],"parent_version":null,"progress_targets_addressed":["Material independence from sealed P1","Eligible measurement/instrumentation primary substrate","Explicit physical transfer, consolidation, eviction, and reconciliation logic"]},"schema_version":1,"structural_mapping":[{"archetype_element":"Fast Volatile Store","domain_realization":"A low-dead-volume, skin-adjacent microfluidic reservoir that rapidly captures the newest sweat but is deliberately too small for durable retention."},{"archetype_element":"Slow Integrated Store","domain_realization":"A removable, sealed strip of indexed sorbent lanes that preserves an ordered series of dried, chemically stabilized sweat aliquots for later laboratory assay."},{"archetype_element":"Read/Write Routing Rule","domain_realization":"Fresh sweat enters only the current liquid reservoir; completed aliquots move one way into archive lanes; laboratory assays read the archive, while calibration blanks bypass the skin-facing reservoir."},{"archetype_element":"Transfer Trigger or Cadence","domain_realization":"A fixed reservoir fill volume reaches a passive capillary burst threshold and transfers the aliquot without software, a pump, or operator timing."},{"archetype_element":"Consolidation Transform","domain_realization":"Sorption, chelation, preservative dissolution, and membrane-assisted drying convert a reactive liquid aliquot into a durable specimen."},{"archetype_element":"Promotion and Eviction Rule","domain_realization":"Each full aliquot is promoted to the next unused archive lane; successful discharge empties the reservoir for fresh sweat, while underfilled final material remains visibly incomplete and is excluded rather than silently promoted."},{"archetype_element":"Interference and Overwrite Guard","domain_realization":"One-way capillary geometry, hydrophobic lane barriers, limited reservoir volume, and a containment membrane reduce backflow, mixing, overwriting, and environmental contamination."},{"archetype_element":"Freshness and Authority Marker","domain_realization":"Reservoir occupancy identifies the current volatile aliquot; numbered dried lanes identify transferred specimens, but only lanes passing integrity and calibration checks are authoritative for assay."},{"archetype_element":"Consistency Reconciliation Check","domain_realization":"A parallel inert-dye witness, lane-mass measurements, blanks, and ordered coding reveal incomplete transfer, cross-lane carryover, skipped lanes, or mismatch between physical sequence and assay results."}],"substrate_contract":{"counterfactual_independence":"Removing software, databases, models, training protocols, incentives, and information-routing systems does not remove the essential effect: capillary pressure still captures and transfers aliquots, sorbent chemistry still stabilizes them, barriers still separate them, and the physical strip still retains their order for later assay.","forbidden_channel_audit":"No governance rule, staff workflow, algorithm, digital controller, or data platform causes capture, transfer, isolation, stabilization, or durable retention. Labels and laboratory procedures support interpretation and safety only; replacing them cannot substitute for the microfluidic valves, sorbent lanes, preservative chemistry, drying membrane, and one-way barriers.","primary_allowed_process":"MEASUREMENT_INSTRUMENTATION"},"title":"Passive Fast-Reservoir to Stabilized Sweat Archive","version":0},"schema_version":1}