{"abstention_reason":null,"arm":"SUBSTRATE_DIVERSE_P2","candidate_id":"multiple_testing_discipline__library_information_science__SUBSTRATE_DIVERSE_P2","cell_id":"multiple_testing_discipline__library_information_science","decision":"PROPOSAL","experiment_id":"eoa_inverse_innovation_exp13_second_slot_policy60_20260806","proposal":{"actors":["Preservation conservator who defines and conducts post-leak sampling","Facilities or environmental-health specialist who assesses moisture and occupational hazards","Special-collections curator responsible for access and collection context","Laboratory technician who performs blinded confirmation assays","Library director or delegated emergency authority who approves closures and remediation"],"affected_objective":"Detect genuinely active mold after water incidents while avoiding unnecessary room closures, chemical treatment, disposal, or stigmatizing catalog notes caused by the most extreme reading among many screened locations.","arm":"SUBSTRATE_DIVERSE_P2","authority_safety":{"authorized_first_step":"The preservation conservator may run a non-destructive, read-only validation using paired samples from inert test surfaces and routine environmental sites; no result from this validation may alter access or trigger treatment.","decision_authority":"Only the library director or formally delegated emergency authority, advised by preservation and environmental-health specialists, may approve a closure, chemical treatment, or collection isolation after physical confirmation and contextual safety review.","excluded_actions":["No collection disposal, fungicide application, room closure, or permanent catalog warning from a discovery-screen result alone","No sampling that abrades, stains, wets, or otherwise damages collection material without conservator approval","No opening or reassignment of sealed confirmation chambers after discovery results are known","No reduction of ventilation or personal protective equipment while a suspected hazard remains unresolved","No inference that a negative surface assay proves an area safe when moisture, odor, visible growth, or occupant symptoms indicate otherwise"],"halt_rollback":"Halt if paired specimens cannot be traced, sterile blanks show contamination, chamber seals fail, assay controls fall outside specification, or discovery results influence confirmation interpretation. Quarantine the affected batch, disregard its status assignments, maintain precautionary protections based on independent safety evidence, and repeat only with a new cassette and fresh specimens."},"baseline":"After a leak or humidity excursion, staff take many handheld fluorescence or surface-swab readings across shelves, boxes, walls, and ventilation points. The highest readings receive attention under a per-reading cutoff even when residue, instrument noise, or ordinary background variation could explain an extreme value among the many sites examined.","candidate_id":"multiple_testing_discipline__library_information_science__SUBSTRATE_DIVERSE_P2","causal_chain":["A post-incident survey measures many surfaces and locations, creating many opportunities for background residue or instrument noise to cross an ordinary single-reading cutoff.","Attention concentrates on the most extreme readings, while the number of sampled sites and negative measurements becomes less salient.","An unconfirmed extreme can therefore be interpreted as active mold and precipitate disruptive preservation or access action.","A mechanically indexed cassette gives every planned site one numbered pair of sterile collection media and one breakaway attempt tab, physically bounding and preserving the survey family.","Adjacent paired specimens enter separate chambers at collection: one chamber supports rapid discovery measurement, while its mate remains sealed and unavailable during search.","A cassette-specific comparator strip, calibrated to the number of occupied discovery positions, raises the promotion threshold as the family grows.","Only a site passing that family-calibrated comparator becomes a candidate, and every other occupied position remains visible as a completed null or rejected look.","The untouched mate from a promoted site undergoes a blinded orthogonal viability assay with positive, negative, and field-blank controls.","Only concordant fresh-specimen evidence can change the physical status tag from exploratory to confirmed and make consequential action eligible.","The director receives the intact cassette record, control results, and conservation context before deciding whether any isolation or remediation is warranted."],"cell_id":"multiple_testing_discipline__library_information_science","consequence":"Chance extremes, fluorescent residues, or handling contamination can be mistaken for viable mold, causing needless closures, hazardous chemical use, conservation work, access loss, or damaging descriptive labels; conversely, an opaque flood of alarms can also desensitize staff to genuine hazards.","diversity_from_prior_proposals":"Unlike P1's collection-use analytics, claim registry, and prospective circulation confirmation, this opportunity concerns biological preservation-hazard measurements after water incidents. Its affected problem is false active-mold designation, its intervention is a mechanically indexed split-specimen assay cassette, and its causal path operates through physical sample separation, batch-calibrated measurement, and orthogonal biological confirmation rather than collection-decision analytics.","experiment_id":"eoa_inverse_innovation_exp13_second_slot_policy60_20260806","intervention":"Use a disposable, mechanically indexed split-specimen cassette for post-leak mold surveys. Before sampling, fit the cassette with a comparator strip manufactured for its occupied family size and assign each planned site one numbered pair of sterile media. Sampling separates adjacent specimens immediately: the discovery specimen enters a rapid fluorescence or immunochemical assay chamber, while the confirmation specimen is irreversibly sealed behind a tamper-evident shutter. Each opened pair breaks an attempt tab, leaving a physical inventory of all sampled sites, including nulls. A discovery chamber may be promoted only when its signal exceeds the cassette's family-calibrated reference band. The corresponding sealed mate is then sent, under blinded identifiers, to an orthogonal viability assay such as culture plus microscopy. Positive, negative, and field-blank chambers validate the batch. Physical status tags distinguish exploratory, family-qualified, confirmed, rejected, and invalid results; only an uncontaminated, concordant confirmation is eligible for consequential review.","mechanism_mapping":[{"counterfactual_removal":"Without immediate physical separation and the sealed shutter, the specimen used to find an extreme could be retested, resampled selectively, or contaminated while serving as its own confirmation.","mechanism_slug":"holdout_validation","role":"The sealed mate is untouched biological evidence reserved before any discovery reading is observed."},{"counterfactual_removal":"Without the family-size comparator, every additional sampled site would retain the same permissive promotion cutoff and increase the chance that background variation creates a candidate.","mechanism_slug":"bonferroni_like_correction","role":"A pre-calibrated physical reference band implements a conservative familywise promotion threshold for the occupied cassette."},{"counterfactual_removal":"Without the orthogonal viability measurement, nonliving residue or discovery-assay interference could remain indistinguishable from active mold.","mechanism_slug":"confirmatory_follow_up","role":"Culture and microscopy test the selected claim through a different physical and biological measurement process."},{"counterfactual_removal":"Without numbered pairs and breakaway attempt tabs, negative or inconvenient sampled sites could disappear from the evidentiary family.","mechanism_slug":"claim_registry","role":"The cassette itself preserves the count, identity, completion state, and disposition of every planned physical look."},{"counterfactual_removal":"Without mutually exclusive physical tags, a bright discovery chamber could be presented as confirmed despite never passing the independent assay.","mechanism_slug":"metric_hierarchy","role":"Status tags keep screening evidence subordinate to controlled, orthogonally confirmed evidence."}],"nearest_rivals":["Ordinary moisture monitoring, which detects environmental conditions conducive to mold but does not correct interpretation of the most extreme result among many biological screens","A single fixed fluorescence cutoff, which standardizes individual readings but becomes increasingly permissive as more locations are sampled","General laboratory quality control, which detects contamination or assay failure but does not by itself make the discovery threshold reflect the number of searched sites","A preservation emergency checklist, which coordinates response but does not create physically independent confirmation evidence","Representative environmental sampling, which addresses biased site selection rather than false discoveries created by many measured sites"],"negative_tests":{"intervention_falsifier":"In a blinded seeded-surface trial, the cassette is falsified as an operative multiplicity guardrail if its batch-level false promotion rate does not fall relative to ordinary per-reading screening, if sealed mates show evidence of prior access or cross-contamination, or if promoted sterile sites frequently pass the orthogonal viability assay despite valid controls.","problem_falsifier":"The multiplicity problem is absent if the incident presents one genuinely pre-specified sampling location and assay, no alternative sites or thresholds are inspected, all outcomes are retained, and consequential action follows independent hazard evidence rather than selection of an extreme from a family.","risks":["Adjacent paired specimens may differ when growth is highly localized, producing genuine discovery-confirmation disagreement.","Culture can miss dormant, slow-growing, or nonculturable organisms, while microscopy can require expert interpretation.","Cassette materials or field handling may contaminate specimens despite control chambers.","A conservative family-calibrated threshold may miss weak but consequential contamination.","Manufactured comparator bands must remain stable across temperature, shelf life, assay lots, and reader illumination.","Sampling collection surfaces may itself pose conservation risk and therefore requires inert-contact or approved minimally invasive methods.","A negative assay must not override visible growth, persistent moisture, occupant symptoms, or other independent safety evidence.","Physical tags and shutters could be bypassed unless tamper evidence is inspected."],"strongest_counterevidence":"If reconstructed incident records show that suspected active mold is rarely chosen from broad surface searches, or blinded trials show that extreme discovery readings almost always correspond to viable growth on independent specimens regardless of family size, repeated-testing false positives would not materially explain current preservation actions."},"next_evidence_step":"Conduct one bench validation with no collection contact: prepare inert archival-board coupons containing blinded viable mold, nonviable fungal residue, fluorescent cleaning residue, and sterile controls. Sample them with cassettes configured for several predeclared family sizes, include field blanks, and compare ordinary per-reading screening against the cassette comparator and sealed-mate confirmation path. Measure batch-level false promotions, true-positive retention, seal integrity, cross-contamination, missing attempt tabs, and blinded agreement between discovery and viability assays. Stop after the predeclared batches; authorize no operational closure or treatment from the results.","observable_state":"During leak response, a survey sheet or handheld reader contains dozens of surface measurements, but the preservation escalation record highlights a few high signals without a tamper-evident physical inventory of all sampled locations, a threshold tied to family size, or an independently sealed specimen collected before the selected result was known.","prior_art_status":"UNSEARCHED","problem":"Post-leak preservation surveys may screen many shelves, enclosures, wall areas, and air-handling locations for active mold. When each rapid fluorescence or swab reading is judged against an ordinary single-reading cutoff, the growing family of sites creates repeated opportunities for residue, background spores, handling contamination, or instrument noise to yield an impressive extreme. Selecting that extreme without untouched biological confirmation can convert a screening artifact into a consequential mold designation.","proposal_index":2,"remaining_contrastive_claim":"This is specifically a many-site biological-measurement intervention: the number of physical sampling opportunities changes the promotion reference, every attempted site leaves a material trace, and the selected claim must survive an independently sealed orthogonal assay. Neither a preservation checklist, a moisture sensor, nor ordinary assay quality control supplies that combination.","revision_record":{"claim_changes":[],"conceptual_changes":[],"evidence_changes":[],"operational_changes":[],"parent_version":null,"progress_targets_addressed":["Create a second opportunity materially independent of collection-weeding analytics","Make measurement instrumentation and biological assay processes the primary causal substrate","Preserve the many-looks, adjusted-standard, discovery-record, status-boundary, and independent-confirmation structure","Bound authority and begin with a non-collection bench validation"]},"schema_version":1,"structural_mapping":[{"archetype_element":"Many attempted claims","domain_realization":"Rapid active-mold screens across numerous shelves, enclosures, walls, and ventilation locations after one water incident"},{"archetype_element":"Ordinary single-claim interpretation","domain_realization":"Each fluorescence or swab value is compared with a fixed per-reading cutoff irrespective of how many sites were screened."},{"archetype_element":"Inflated false-positive opportunity","domain_realization":"Background residue, ubiquitous spores, handling contamination, and instrument noise receive repeated chances to produce the survey's most alarming reading."},{"archetype_element":"Claim family","domain_realization":"All occupied, numbered specimen pairs in one incident cassette, fixed before discovery measurements begin"},{"archetype_element":"Multiplicity inventory and discovery record","domain_realization":"Numbered chambers, broken attempt tabs, control positions, and retained physical status tags show every planned and completed look."},{"archetype_element":"Error-risk policy and adjusted rule","domain_realization":"A conservative, family-size-specific comparator band governs which discovery specimens can advance."},{"archetype_element":"Exploratory–confirmatory boundary","domain_realization":"Rapid assay chambers generate leads; tamper-sealed adjacent specimens remain unavailable until selection is complete."},{"archetype_element":"Claim-status labeling","domain_realization":"Mutually exclusive exploratory, family-qualified, confirmed, rejected, and invalid tags remain attached to cassette positions."},{"archetype_element":"Confirmation before costly action","domain_realization":"A promoted site requires valid controls and concordant culture-plus-microscopy evidence before closure, treatment, isolation, or permanent description becomes eligible."}],"substrate_contract":{"counterfactual_independence":"If all software, databases, automated routing, governance registries, and digital controls are removed, the intervention's essential effect remains: paired media physically separate discovery from confirmation, a tamper-evident shutter protects the untouched mate, a family-specific comparator changes the measurable promotion boundary, attempt tabs preserve sampled nulls, and an orthogonal biological assay tests viability.","forbidden_channel_audit":"Governance supplies authorization and safety limits, and computation may optionally calculate or archive results, but neither creates the evidentiary separation or confirmation. No algorithm selects sites, no database is required to preserve attempts, and no digital gate is needed to prevent reuse of the discovery specimen. The core causal operations are specimen collection, mechanical indexing and sealing, optical or immunochemical comparison, microbial growth, and microscopy.","primary_allowed_process":"MEASUREMENT_INSTRUMENTATION"},"title":"Split-Specimen Mold Confirmation Cassette for Archive Leak Triage","version":0},"schema_version":1}