Update: Clinically Significant Cytochrome P‐450 Drug Interactions¶
Michalets. (1998). Update: Clinically Significant Cytochrome P‐450 Drug Interactions.
Cited by¶
1 citation across 1 artifact.
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Domain-specific¶
- Pharmacokinetic Interaction
- CYP3A4 inhibition by ketoconazole, clarithromycin, or grapefruit juice raises plasma concentrations of co-administered substrates like statins, immunosuppressants, and certain antihistamines; CYP3A4 induction by rifampicin or carbamazepine lowers them, causing therapeutic failure of oral contraceptives or anticoagulants
This sourceReview of the cytochrome P450 isoenzymes establishing that inhibition and induction disturb microsomal drug metabolism and that knowing their substrates, inhibitors and inducers allows clinically significant interactions to be predicted.
Supported in partVerified against the publisher's abstract
“In addition to inhibition and induction, microsomal drug metabolism is affected by genetic polymorphisms, age, nutrition, hepatic disease, and endogenous chemicals.”
- CYP3A4 inhibition by ketoconazole, clarithromycin, or grapefruit juice raises plasma concentrations of co-administered substrates like statins, immunosuppressants, and certain antihistamines; CYP3A4 induction by rifampicin or carbamazepine lowers them, causing therapeutic failure of oral contraceptives or anticoagulants
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