Stereochemistry, a basis for sophisticated nonsense in pharmacokinetics and clinical pharmacology

Ariëns, E. J. (1984). Stereochemistry, a basis for sophisticated nonsense in pharmacokinetics and clinical pharmacology. European Journal of Clinical Pharmacology, 663-668.

Type

Journal article

Intellectual base

Primary research

Year

1984

Pages

663-668

DOI

10.1007/bf00541922

DOI registrant

Springer Nature

Link

https://doi.org/10.1007/bf00541922

Cited by

1 citation across 1 artifact.

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Mechanisms

• Polarity or Orientation Flip Probe
  • The two enantiomers turn out to differ sharply on both, which the formula alone could never have revealed.

    This sourceExplains that enantiomers can differ materially in therapeutic activity and adverse effects, so treating a racemate as a single undifferentiated drug can mislead.

Verification

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Does it back the claim? Not recorded. The single citation of this work carries no recorded support check.

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Registry ID ref:0221d872ad72 · see in the full table