Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies

Chou, T. -. (2006). Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Pharmacological Reviews, 58(3), 621-681.

Type

Journal article

Intellectual base

Primary research

Year

2006

Link

https://doi.org/10.1124/pr.58.3.10matched

Cited from

biology_ecology

Cited by

1 citation across 1 artifact.

Each citation links to the sentence it supports in the citing article.

Primes

• Synergy and Antagonism
  • Reasoning about synergy and antagonism proceeds by specifying a baseline, measuring or modeling the combined effect, computing the deviation, and attributing mechanism, as Chou (2006) systematized in his theoretical and computational treatment of drug-combination studies.

    This sourceSystematic treatment of statistical formalization (median-effect equation, combination-index analysis, isobolograms) for measuring deviations from baseline in drug combinations.

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