Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies¶
Chou, T. -. (2006). Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Pharmacological Reviews, 58(3), 621-681.
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Primes¶
- Synergy and Antagonism
- Reasoning about synergy and antagonism proceeds by specifying a baseline, measuring or modeling the combined effect, computing the deviation, and attributing mechanism, as Chou (2006) systematized in his theoretical and computational treatment of drug-combination studies.
This sourceSystematic treatment of statistical formalization (median-effect equation, combination-index analysis, isobolograms) for measuring deviations from baseline in drug combinations.
- Reasoning about synergy and antagonism proceeds by specifying a baseline, measuring or modeling the combined effect, computing the deviation, and attributing mechanism, as Chou (2006) systematized in his theoretical and computational treatment of drug-combination studies.
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