Impact of Active Placebo Controls on Estimated Drug Effects in Randomised Trials¶
Laursen, D. R., Nejstgaard, C. H., Bjørkedal, E., Frost, A. D., Hansen, M. R., Paludan-Müller, A. S., Prosenz, J., et al. (2023). Impact of Active Placebo Controls on Estimated Drug Effects in Randomised Trials: A Systematic Review of Trials with Both Active Placebo and Standard Placebo. Cochrane Database of Systematic Reviews, 2023(3).
Cited by¶
1 citation across 1 artifact.
Each citation links to the sentence it supports in the citing article.
Mechanisms¶
- Sham or Placebo Control
- An over-active sham imposes burden or risk beyond what the design can justify, and an active placebo that itself nudges the outcome quietly changes the estimand you thought you were measuring.
This sourceShows that an active placebo can itself affect outcomes or blinding and thereby alter the estimated treatment effect.
- An over-active sham imposes burden or risk beyond what the design can justify, and an active placebo that itself nudges the outcome quietly changes the estimand you thought you were measuring.
Verification¶
Does it exist? Confirmed. This work's DOI resolves to a registered record, which fixes its identity. That is all it fixes.
Does it back the claim? Not recorded. The single citation of this work carries no recorded support check.
Support is checked per citation rather than per work — the same source can be cited soundly in one article and wrongly in another. Per-citation recording began recently, so a citation with no recorded check is a gap in the record rather than evidence it went unchecked.
See how references were verified.
Registry ID ref:05beca09eadd · see in the full table