Hormesis¶
Calabrese, E. J., & Baldwin, L. A. (2001). Hormesis: U-Shaped Dose Responses and Their Centrality in Toxicology. Trends in Pharmacological Sciences, 22(6), 285-291.
Cited by¶
1 citation across 1 artifact.
Each citation links to the sentence it supports in the citing article.
Mechanisms¶
- Exposure Dose Curve
- The classic error is extrapolation: assuming the slope keeps going, or that a safe threshold exists where none was tested, or that a low-dose effect predicts the high-dose one — when some responses are non-monotonic, the very possibility captured by hormesis.
This sourceShows that dose responses can be non-monotonic and hormetic, undermining untested linear, threshold, and cross-dose extrapolations.
- The classic error is extrapolation: assuming the slope keeps going, or that a safe threshold exists where none was tested, or that a low-dose effect predicts the high-dose one — when some responses are non-monotonic, the very possibility captured by hormesis.
Verification¶
Does it exist? Confirmed. This work's DOI resolves to a registered record, which fixes its identity. That is all it fixes.
Does it back the claim? Not recorded. The single citation of this work carries no recorded support check.
Support is checked per citation rather than per work — the same source can be cited soundly in one article and wrongly in another. Per-citation recording began recently, so a citation with no recorded check is a gap in the record rather than evidence it went unchecked.
See how references were verified.
Registry ID ref:063299fda347 · see in the full table