Why Does Drug Resistance Readily Evolve but Vaccine Resistance Does Not?¶
Kennedy, D. A., & Read, A. F. (2017). Why Does Drug Resistance Readily Evolve but Vaccine Resistance Does Not?. Proceedings of the Royal Society B, 284(1851).
Cited by¶
1 citation across 1 artifact.
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Primes¶
- Intervention-Coupled Harm
- in military and humanitarian intervention (protective force deters through the same coercive capacity that produces civilian harm; blockades pressure through the same supply-restriction that produces humanitarian crisis), in ecological restoration (prescribed burns reduce fuel load via the same combustion that kills sensitive species), and in population-level vaccination (sterilising immunity reduces transmission via the same selection pressure that drives antigenic escape).
This sourceAnalyzes how the selection pressure that gives sterilizing immunity its transmission-blocking benefit also drives antigenic escape.
Supported in partVerified against the work's full text
Kennedy and Read discuss vaccine-driven selection for resistance, but argue it rarely produces escape and say nothing on blockades, force or prescribed burns.
“Yet drugs and vaccines both profoundly suppress pathogen fitness and so both should generate tremendous evolutionary pressure for resistance”
- in military and humanitarian intervention (protective force deters through the same coercive capacity that produces civilian harm; blockades pressure through the same supply-restriction that produces humanitarian crisis), in ecological restoration (prescribed burns reduce fuel load via the same combustion that kills sensitive species), and in population-level vaccination (sterilising immunity reduces transmission via the same selection pressure that drives antigenic escape).
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