The Molecular Basis of Tolerance.

Pietrzykowski, A. Z., & Treistman, S. N. (2008). The Molecular Basis of Tolerance. Alcohol Research & Health, 31(4), 298-309.

Type

Journal article

Intellectual base

Primary research

Year

2008

Volume

31

Issue

4

Pages

298-309

Link

https://pmc.ncbi.nlm.nih.gov/articles/PMC3860466/

Cited from

engineering_design

Cited by

1 citation across 1 artifact.

Each citation links to the sentence it supports in the citing article.

Primes

• Normalization of Deviance
  • And in behavioral and clinical psychology, tolerance development and shifting conflict thresholds in harmful dynamics follow the same shape.

    This sourceReviews tolerance as "the diminished response to alcohol or other drugs over the course of repeated or prolonged exposure," an adaptation that resets the baseline response as exposure accumulates - the behavioral/clinical-psychology instance of an operating standard (here, physiological response) drifting under repeated benign sampling. PMID 23584007.

    Supported in partVerified against the work's full text

    The review documents alcohol/drug tolerance as a shifting physiological set point; it says nothing about conflict thresholds or behavior in harmful relational dynamics.

    “Multiple, frequent drug exposures cause a progressively diminishing response to a drug (i.e., the development of tolerance).”

    Read by an automated reader; not a human review. How support was checked

Verification

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