Checkpoints¶
Hartwell, L. H., & Weinert, T. A. (1989). Checkpoints: Controls That Ensure the Order of Cell Cycle Events. Science, 246(4930), 629-634.
Cited by¶
2 citations across 2 artifacts.
Each citation links to the sentence it supports in the citing article.
Primes¶
- Orchestration
- Differentiated components, a state-carrying locus, and adaptive assignment are all present with nobody occupying the role of a conductor.
This sourceEstablishes checkpoint control that gates progression on observed completion of prior events rather than on elapsed time, with no actor occupying the directing role.
- Differentiated components, a state-carrying locus, and adaptive assignment are all present with nobody occupying the role of a conductor.
- Self Checking
- In biology, cell-cycle checkpoints check replication and chromosomal attachment against expected state and halt on disagreement, while immune self/nonself discrimination compares circulating antigens against tolerized self-signatures.
This sourceDefines cell-cycle checkpoints that verify completion/correctness of a stage and halt progression on failure; loss of the checkpoint permits division with damaged or mis-segregated chromosomes.
Supported in partVerified against the publisher's abstract
Hartwell & Weinert's abstract defines cell-cycle checkpoints as controls enforcing dependency between cell-cycle events, backing the cell-cycle half of the claim but saying nothing about immune self/nonself discrimination.
“Control mechanisms enforcing dependency in the cell cycle are here called checkpoints.”
- In biology, cell-cycle checkpoints check replication and chromosomal attachment against expected state and halt on disagreement, while immune self/nonself discrimination compares circulating antigens against tolerized self-signatures.
Verification¶
Does it exist? Confirmed. This work's DOI resolves to a registered record, which fixes its identity. That is all it fixes.
Does it back the claim? Read against the text for 1 of 2 citations: 1 supported in part. Each verdict is shown under its citation below, with what in the work backs the sentence.
Support is checked per citation rather than per work — the same source can be cited soundly in one article and wrongly in another. Per-citation recording began recently, so a citation with no recorded check is a gap in the record rather than evidence it went unchecked.
See how references were verified.
Registry ID ref:080a248c4163 · see in the full table