Checkpoints¶
Hartwell, L. H., & Weinert, T. A. (1989). Checkpoints: Controls That Ensure the Order of Cell Cycle Events. Science, 246(4930), 629-634.
Cited by¶
2 citations across 2 artifacts.
Each citation links to the sentence it supports in the citing article.
Primes¶
- Orchestration
- Differentiated components, a state-carrying locus, and adaptive assignment are all present with nobody occupying the role of a conductor.
This sourceEstablishes checkpoint control that gates progression on observed completion of prior events rather than on elapsed time, with no actor occupying the directing role.
- Differentiated components, a state-carrying locus, and adaptive assignment are all present with nobody occupying the role of a conductor.
- Self Checking
- In biology, cell-cycle checkpoints check replication and chromosomal attachment against expected state and halt on disagreement, while immune self/nonself discrimination compares circulating antigens against tolerized self-signatures.
This sourceDefines cell-cycle checkpoints that verify completion/correctness of a stage and halt progression on failure; loss of the checkpoint permits division with damaged or mis-segregated chromosomes.
- In biology, cell-cycle checkpoints check replication and chromosomal attachment against expected state and halt on disagreement, while immune self/nonself discrimination compares circulating antigens against tolerized self-signatures.
Verification¶
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