The Determination and Interpretation of the Therapeutic Index in Drug Development.¶
Muller, P. Y., & Milton, M. N. (2012). The Determination and Interpretation of the Therapeutic Index in Drug Development. Nature Reviews Drug Discovery, 11(10), 751-761.
Cited by¶
1 citation across 1 artifact.
Each citation links to the sentence it supports in the citing article.
Mechanisms¶
- Clinical Titration Adjustment
- It respects the therapeutic window — the band between too little to work and enough to harm — by creeping into it rather than leaping.
This sourceDefines therapeutic index by balancing exposure that produces efficacy against exposure that produces toxicity.
- It respects the therapeutic window — the band between too little to work and enough to harm — by creeping into it rather than leaping.
Verification¶
Does it exist? Confirmed. This work's DOI resolves to a registered record, which fixes its identity. That is all it fixes.
Does it back the claim? Not recorded. The single citation of this work carries no recorded support check.
Support is checked per citation rather than per work — the same source can be cited soundly in one article and wrongly in another. Per-citation recording began recently, so a citation with no recorded check is a gap in the record rather than evidence it went unchecked.
See how references were verified.
Registry ID ref:09586a814985 · see in the full table