Operational models of pharmacological agonism

Black, J. W., & Leff, P. (1983). Operational models of pharmacological agonism. Proceedings of the Royal Society of London B: Biological Sciences, 141-162.

Type

Journal article

Intellectual base

Primary research

Year

1983

Link

https://doi.org/10.1098/rspb.1983.0093matched

Cited from

pharmacology_toxicology

Cited by

2 citations across 2 artifacts.

Primes

• PK/PD Modeling (Pharmacokinetics / Pharmacodynamics)
  • Structurally-faithful non-formal case — advertising-budget allocation with time-delayed brand-response: A marketing team models advertising budget (dose) → share-of-voice and reach time course ("PK" — how ad spend translates to audience exposure with absorption-like ramp-up and exponential decay as campaign ends) → brand-awareness and consideration response ("PD" — effect of exposure on lagged brand metrics with saturation at high exposure and delay between exposure and response — effect-compartment lag), with the saturating concentration-effect leg formally an instance of the operational model of agonism due to Black and Leff (1983).
• Receptor Saturation
  • As Black and Leff (1983) emphasize in their operational model of agonism,

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