The Effect of Plasma Protein Binding on In Vivo Efficacy

Dennis A. Smith, L. D., & Kerns, E. H. (2010). The Effect of Plasma Protein Binding on In Vivo Efficacy: Misconceptions in Drug Discovery.

Type

Unclassified

Intellectual base

Unclassified

Year

2010

DOI

10.1038/nrd3287

Link

https://doi.org/10.1038/nrd3287

Cited by

1 citation across 1 artifact.

Domain-specific

• Tissue selectivity
  • … agonistically in one tissue and antagonistically in another because receptor and coregulator contexts differ despite systemic exposure. to A peripherally selective compound shows low central exposure because it poorly crosses the blood-brain barrier or is actively effluxed, reducing central effects at a stated dose..

Verification

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Registry ID ref:0a85bf543d4d · see in the full table