A Pharmacology Primer¶
Kenakin, T. (2014). A Pharmacology Primer: Techniques for More Effective and Strategic Drug Discovery. Academic Press.
Cited by¶
1 citation across 1 artifact.
Each citation links to the sentence it supports in the citing article.
Primes¶
- Intrinsic Ceiling vs Input
- Pharmacology (the canonical case): the efficacy-versus-potency distinction — efficacy (Emax) is the maximum response regardless of dose, potency (EC50) the dose for half-maximal response; a partial agonist has a lower, intrinsic ceiling, which is the structural basis of buprenorphine's bounded respiratory-depression safety.
This sourceDefines efficacy (Emax, the intrinsic ceiling) versus potency (EC50, the input to approach it), full versus partial agonists, and the bounded-ceiling safety property of partial agonists.
- Pharmacology (the canonical case): the efficacy-versus-potency distinction — efficacy (Emax) is the maximum response regardless of dose, potency (EC50) the dose for half-maximal response; a partial agonist has a lower, intrinsic ceiling, which is the structural basis of buprenorphine's bounded respiratory-depression safety.
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Registry ID ref:0b07972fea3a · see in the full table