American Heart Association/American College of Cardiology Foundation Guide to Warfarin Therapy¶
Hirsh, J., Fuster, V., Ansell, J., & Halperin, J. L. (2003). American Heart Association/American College of Cardiology Foundation Guide to Warfarin Therapy. Circulation, 107(12), 1692-1711.
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Primes¶
- Selectivity Window
- In pharmacology, the therapeutic window is the dose range that discriminates efficacy from toxicity — below it no benefit, above it harm dominates, with warfarin the paradigm narrow case.
This sourceDefines warfarin's narrow therapeutic window via the INR target band (typically 2-3), with thrombosis below and hemorrhage above as the asymmetric edges.
- In pharmacology, the therapeutic window is the dose range that discriminates efficacy from toxicity — below it no benefit, above it harm dominates, with warfarin the paradigm narrow case.
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