Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for Codeine Therapy in the Context of Cytochrome P450 2D6 (CYP2D6) Genotype¶
Crews. (2011). Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for Codeine Therapy in the Context of Cytochrome P450 2D6 (CYP2D6) Genotype.
Cited by¶
1 citation across 1 artifact.
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Domain-specific¶
- Potency
- Morphine and codeine illustrate the point: morphine is roughly ten times more potent as an analgesic than codeine (the ED50 for analgesia is reached at a much lower dose), but both are full agonists at opioid receptors and can in principle achieve equivalent maximum analgesia given enough dose
This sourceConsensus dosing guideline stating that codeine is bioactivated to morphine by CYP2D6, so its analgesia depends on genotype and it has little effect in poor metabolizers.
Supported in partVerified against the publisher's abstract
“Codeine is bioactivated to morphine, a strong opioid agonist, by the hepatic cytochrome P450 2D6 (CYP2D6)”
- Morphine and codeine illustrate the point: morphine is roughly ten times more potent as an analgesic than codeine (the ED50 for analgesia is reached at a much lower dose), but both are full agonists at opioid receptors and can in principle achieve equivalent maximum analgesia given enough dose
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Registry ID ref:113fe1983757 · see in the full table