Novel Proteinaceous Infectious Particles Cause Scrapie¶
Prusiner, S. B. (1982). Novel Proteinaceous Infectious Particles Cause Scrapie. Science, 216(4542), 136-144.
Cited by¶
1 citation across 1 artifact.
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Primes¶
- Defect
- In biology and medicine, a point mutation in a critical gene produces macroscopic disease (sickle-cell anaemia), and a single misfolded prion can seed cascade misfolding.
This sourceIntroduces the prion — a misfolded protein that catalyzes the conversion of normal protein into more copies of the misfolded form, a single misfolded molecule seeding cascade misfolding.
Supported in partVerified against the publisher's abstract
Prusiner 1982 coins the prion as a proteinaceous infectious particle resistant to nucleic-acid-modifying procedures; its abstract says nothing of sickle-cell point mutations or single-molecule seeding.
“Because the novel properties of the scrapie agent distinguish it from viruses, plasmids, and viroids, a new term "prion" is proposed to denote a small pro teinaceous in fectious particle which is resistant to inactivation by most procedures that modify nucleic acids.”
- In biology and medicine, a point mutation in a critical gene produces macroscopic disease (sickle-cell anaemia), and a single misfolded prion can seed cascade misfolding.
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Registry ID ref:19eeb512ee57 · see in the full table