Randomised Trial of Intravenous Streptokinase, Oral Aspirin, Both, or Neither among 17,187 Cases of Suspected Acute Myocardial Infarction

ISIS-2 Collaborative Group. (1988). Randomised Trial of Intravenous Streptokinase, Oral Aspirin, Both, or Neither among 17,187 Cases of Suspected Acute Myocardial Infarction: ISIS-2. The Lancet, 332(8607), 349-360.

Type

Journal article

Intellectual base

Primary research

Year

1988

Volume

332

Issue

8607

Pages

349-360

ISSN

0140-6736

DOI

10.1016/s0140-6736(88)92833-4

DOI registrant

Elsevier

Link

https://doi.org/10.1016/S0140-6736(88)92833-4

Cited by

1 citation across 1 artifact.

Each citation links to the sentence it supports in the citing article.

Mechanisms

• Subgroup Analysis
  • The cautionary anchor here is famous: a landmark cardiology trial once split its results by astrological birth sign to show how easily subgroup slicing invents effects that are pure noise.

    This sourceUses astrological birth-sign subgroups in a large randomized trial to demonstrate how repeated subgroup analysis can generate chance treatment-effect differences.

Verification

Does it exist? Confirmed. This work's DOI resolves to a registered record, which fixes its identity. That is all it fixes.

Does it back the claim? Not recorded. The single citation of this work carries no recorded support check.

Support is checked per citation rather than per work — the same source can be cited soundly in one article and wrongly in another. Per-citation recording began recently, so a citation with no recorded check is a gap in the record rather than evidence it went unchecked.

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Registry ID ref:1b173904f759 · see in the full table