Handbook of Pharmaceutical Salts¶
Stahl, P. H., & Wermuth, C. G. (2002). Handbook of Pharmaceutical Salts: Properties, Selection, and Use. Wiley.
Cited by¶
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Domain-specific¶
- Solubility
- The conditions dependence of solubility carries specific engineering content: solubility of most solid solutes in water increases with temperature (dissolution is endothermic), allowing hot-solution crystallization as a purification method; solubility of gases in liquids decreases with temperature (Henry's law, c = kH·P, where kH is temperature-dependent) and increases with partial pressure; solubility of ionizable compounds is strongly pH-dependent through protonation equilibria, enabling pharmaceutical salt-form selection to tune aqueous solubility by orders of magnitude
This sourceThe Handbook of Pharmaceutical Salts, whose chapter on the solubility behaviour of acids, bases and their salts gives the pH-solubility profile of ionizable compounds alongside salt formation and selection.
Supported in partVerified against a saved copy of the source
“solubility of an ionizable compound as a function of pH, known as the pH-solubility profile, can be determined”
- The conditions dependence of solubility carries specific engineering content: solubility of most solid solutes in water increases with temperature (dissolution is endothermic), allowing hot-solution crystallization as a purification method; solubility of gases in liquids decreases with temperature (Henry's law, c = kH·P, where kH is temperature-dependent) and increases with partial pressure; solubility of ionizable compounds is strongly pH-dependent through protonation equilibria, enabling pharmaceutical salt-form selection to tune aqueous solubility by orders of magnitude
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