Structure and Function of the Feed-Forward Loop Network Motif¶
Mangan, S., & Alon, U. (2003). Structure and Function of the Feed-Forward Loop Network Motif. Proceedings of the National Academy of Sciences, 11980-11985.
Cited by¶
1 citation across 1 artifact.
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Primes¶
- Motif
- The feed-forward loop is over-represented — it occurs far more than chance — and the prime's enrichment-relative-to-baseline argument is exactly the inference that this over-representation reveals function: the coherent feed-forward loop with AND logic implements a sign-sensitive delay that filters out brief input spikes while passing sustained signals.
This sourceShows the coherent feed-forward loop with AND logic implements a sign-sensitive delay that filters brief input spikes while passing sustained signals.
SupportedVerified against the work's full text
Mangan and Alon state network motifs occur far more often than in randomized networks, the FFL among the most significant, and the coherent AND-gate FFL acts as a sign-sensitive delay rejecting short pulses.
“An equivalent way to describe the sign-sensitive delay function of the coherent FFL is sign-sensitive persistence detection ( 6 ): it responds only to persistent Sx stimuli and rejects short Sx pulses.”
- The feed-forward loop is over-represented — it occurs far more than chance — and the prime's enrichment-relative-to-baseline argument is exactly the inference that this over-representation reveals function: the coherent feed-forward loop with AND logic implements a sign-sensitive delay that filters out brief input spikes while passing sustained signals.
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Registry ID ref:1c380424b50c · see in the full table