Axonal transport deficits and neurodegenerative diseases¶
Millecamps, & Julien. (2013). Axonal transport deficits and neurodegenerative diseases. Nature Reviews Neuroscience.
Cited by¶
1 citation across 1 artifact.
Each citation links to the sentence it supports in the citing article.
Domain-specific¶
- Axonal Transport
- The reliance on continuous active transport makes the system fragile to disruption: when axonal transport fails — through microtubule destabilization, motor-protein mutation or sequestration, or energy depletion — the distant terminal is the first to suffer, producing the characteristic dying-back neuropathy pattern in which synapses and distal axon segments degenerate while the soma remains intact, a signature seen in several neurodegenerative diseases including Charcot-Marie-Tooth disease, several subtypes of which arise from mutations in the transport machinery itself, and in the early stages of Alzheimer's, Parkinson's, and ALS pathology
This sourceReview finding that anterograde axonal transport supplies protein, lipid, mRNA and mitochondria to the distal synapse while retrograde transport clears misfolded and aggregated protein and carries distal trophic signals to the soma, and that transport deficits might contribute to the pathogenesis of Alzheimer's disease, Charcot-Marie-Tooth disease, ALS and Parkinson's disease.
Supported in partVerified against the source
- The reliance on continuous active transport makes the system fragile to disruption: when axonal transport fails — through microtubule destabilization, motor-protein mutation or sequestration, or energy depletion — the distant terminal is the first to suffer, producing the characteristic dying-back neuropathy pattern in which synapses and distal axon segments degenerate while the soma remains intact, a signature seen in several neurodegenerative diseases including Charcot-Marie-Tooth disease, several subtypes of which arise from mutations in the transport machinery itself, and in the early stages of Alzheimer's, Parkinson's, and ALS pathology
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