Kinesin superfamily motor proteins and intracellular transport¶
Hirokawa. (2009). Kinesin superfamily motor proteins and intracellular transport. Nature Reviews Molecular Cell Biology.
Cited by¶
1 citation across 1 artifact.
Each citation links to the sentence it supports in the citing article.
Domain-specific¶
- Axonal Transport
- Motor proteins accomplish this supply: kinesin walks along microtubule tracks in the anterograde direction (soma to terminal), carrying vesicles, mitochondria, and newly synthesized proteins outward; dynein walks in the retrograde direction (terminal to soma), returning degraded proteins, recycled membrane components, and retrograde signaling molecules including neurotrophins (such as nerve growth factor) that carry information about synaptic activity and target-tissue health back to the nucleus
This sourceReview of the kinesin superfamily establishing that these motors directionally transport membranous organelles, protein complexes and mRNAs and that their cargo-recognition and direction-determining mechanisms have been identified.
Supported in partVerified against the work's full text
“The mechanisms by which different kinesins recognize and bind to specific cargos, as well as how kinesins unload cargo and determine the direction of transport, have now been identified.”
- Motor proteins accomplish this supply: kinesin walks along microtubule tracks in the anterograde direction (soma to terminal), carrying vesicles, mitochondria, and newly synthesized proteins outward; dynein walks in the retrograde direction (terminal to soma), returning degraded proteins, recycled membrane components, and retrograde signaling molecules including neurotrophins (such as nerve growth factor) that carry information about synaptic activity and target-tissue health back to the nucleus
Verification¶
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Registry ID ref:20255086408d · see in the full table