Uncovering Cryptic Genetic Variation

Gibson, G., & Dworkin, I. (2004). Uncovering Cryptic Genetic Variation. Nature Reviews Genetics.

Type

Journal article

Intellectual base

Primary research

Year

2004

DOI

10.1038/nrg1426

DOI registrant

Springer Nature

Link

https://doi.org/10.1038/nrg1426

Cited from

biology_ecology

Cited by

1 citation across 1 artifact.

Each citation links to the sentence it supports in the citing article.

Primes

• Selection-Visibility Gate
  • Genetics and development: recessivity, incomplete penetrance and condition-dependent expression all mean an allele's fitness consequence reaches selection only some of the time, which is why populations carry large reservoirs of standing variation that no pressure has ever evaluated.

    This sourceDocuments large reservoirs of standing variation shielded from selection by recessivity, incomplete penetrance and condition-dependent expression.

    Supported in partVerified against the publisher's abstract

    The abstract supports hidden, pervasive genetic variation that is uncovered by environmental or genetic perturbations, but it names no shielding mechanism and does not say any variation escapes evaluation by selection entirely.

    “Cryptic genetic variation is the dark matter of biology: it is variation that is not normally seen, but that might be an essential source of physiological and evolutionary potential. It is uncovered by environmental or genetic perturbations”

    Read by an automated reader; not a human review. How support was checked

Verification

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