Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6): clinical consequences, evolutionary aspects and functional diversity¶
Ingelman-Sundberg, M. (2005). Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6): clinical consequences, evolutionary aspects and functional diversity: clinical consequences, evolutionary aspects and functional diversity. The Pharmacogenomics Journal.
Cited by¶
1 citation across 1 artifact.
Each citation links to the sentence it supports in the citing article.
Domain-specific¶
- Elimination Pathway
- Pharmacogenomic variation in pathway enzymes — CYP2D6 poor versus ultra-rapid metabolizer phenotypes producing roughly 30-fold differences in substrate clearance
This sourceReview of CYP2D6 polymorphism, which produces poor, intermediate, efficient and ultrarapid metaboliser phenotypes and significantly affects the pharmacokinetics of many drugs in clinical use.
Supported in partVerified against the work's full text
“The polymorphism of CYP2D6 significantly affects the pharmacokinetics of about 50% of the drugs in clinical use, which are CYP2D6 substrates.”
- Pharmacogenomic variation in pathway enzymes — CYP2D6 poor versus ultra-rapid metabolizer phenotypes producing roughly 30-fold differences in substrate clearance
Verification¶
Does it exist? Not checked yet. This work's DOI is recorded above but has not been resolved against an external catalogue, so nothing here confirms the work exists.
Does it back the claim? Read against the text for 1 of 1 citation: 1 supported in part. Each verdict is shown under its citation below, with what in the work backs the sentence.
Support is checked per citation rather than per work — the same source can be cited soundly in one article and wrongly in another. Per-citation recording began recently, so a citation with no recorded check is a gap in the record rather than evidence it went unchecked.
See how references were verified.
Registry ID ref:23038080bd8e · see in the full table