Directed Evolution¶
Arnold, F. H. (2018). Directed Evolution: Bringing New Chemistry to Life. Angewandte Chemie International Edition, 4143-4148.
Cited by¶
1 citation across 1 artifact.
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Primes¶
- Fuzzing
- In drug and vaccine development it is combinatorial-library screening, phage display, and random mutagenesis for enzyme engineering — "generate broad random variation, select on a screen for surprises."
This sourceDescribes directed evolution — generating broad random sequence variation by mutagenesis and selecting on a functional screen across iterative rounds — the protein-engineering instance of generate-broad-variation-and-select.
Supported in partVerified against the work's full text
Arnold supports random mutagenesis plus functional screening for enzyme engineering, but says nothing on drug/vaccine screening, combinatorial libraries or phage display.
“Turning instead to random mutagenesis and screening, I quickly realized that such mutations were easy to find and accumulate with the right evolutionary optimization strategy.”
- In drug and vaccine development it is combinatorial-library screening, phage display, and random mutagenesis for enzyme engineering — "generate broad random variation, select on a screen for surprises."
Verification¶
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Registry ID ref:25345c4cd758 · see in the full table