Biomolecular Condensates¶
Banani, S. F., Lee, H. O., Hyman, A. A., & Rosen, M. K. (2017). Biomolecular Condensates: Organizers of Cellular Biochemistry. Nature Reviews Molecular Cell Biology, 18(5), 285-298.
Cited by¶
2 citations across 2 artifacts.
Each citation links to the sentence it supports in the citing article.
Primes¶
- Co-location
- The placement is the intervention; the chemistry that follows is separate.
This sourceDescribes membraneless compartments that concentrate specific molecules within a shared region, raising effective local concentration and the rates of the reactions that follow.
Supported in partVerified against the work's full text
The review shows condensates concentrate reactants and often speed reactions, yet concentration alone does not guarantee faster chemistry, so placement and reaction outcome can come apart.
“However, concentration into a condensed phase does not always produce overall reaction rate acceleration.”
- The placement is the intervention; the chemistry that follows is separate.
- Phase Separation
- Chemistry and materials science (origin) — oil-and-water, alloy demixing on cooling, eutectoid microstructures, polymer blends, glass formation; the canonical substrate where interaction asymmetry and the miscibility boundary were first formalized. Cell biology — membraneless organelles (P-bodies, stress granules, nucleoli) form by liquid-liquid phase separation of intrinsically disordered proteins, a paradigm shift over the past decade.
This sourceReviews membraneless organelles (P-bodies, stress granules, nucleoli) forming by liquid-liquid phase separation driven by multivalent macromolecular interactions.
Supported in partVerified against the work's full text
The review says many membraneless compartments form by liquid-liquid phase separation and that disordered-region proteins are enriched in P bodies and stress granules; it does not say these are formed by IDPs alone.
“IDR-containing proteins are enriched in many Condensates, particularly those that also concentrate RNA, such as P bodies, stress granules, germ granules and many nuclear structures.”
- Chemistry and materials science (origin) — oil-and-water, alloy demixing on cooling, eutectoid microstructures, polymer blends, glass formation; the canonical substrate where interaction asymmetry and the miscibility boundary were first formalized. Cell biology — membraneless organelles (P-bodies, stress granules, nucleoli) form by liquid-liquid phase separation of intrinsically disordered proteins, a paradigm shift over the past decade.
Verification¶
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