Data Monitoring Committees in Clinical Trials¶
Ellenberg, S. S., Fleming, T. R., & DeMets, D. L. (2002). Data Monitoring Committees in Clinical Trials: A Practical Perspective. John Wiley & Sons.
Cited by¶
1 citation across 1 artifact.
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Mechanisms¶
- Pre-Horizon Commitment Gate and Independent Challenge
- … exactly where continuation bias and sponsor incentive would otherwise let commitment drift past the window, and its graded menu buys information without an all-or-nothing choice; a pre-specified stopping rule backed by independent authority is what keeps the freeze from being renegotiated the moment it bites.
This sourceExplains that independent monitoring committees apply prospectively specified stopping guidance so trial continuation is not renegotiated solely after results emerge.
- … exactly where continuation bias and sponsor incentive would otherwise let commitment drift past the window, and its graded menu buys information without an all-or-nothing choice; a pre-specified stopping rule backed by independent authority is what keeps the freeze from being renegotiated the moment it bites.
Verification¶
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