THE EFFECTS OF EXPERIMENTAL DEMYELINATION ON CONDUCTION IN THE CENTRAL NERVOUS SYSTEM¶
MCDONALD, W. I., & SEARS, T. A. (1970). THE EFFECTS OF EXPERIMENTAL DEMYELINATION ON CONDUCTION IN THE CENTRAL NERVOUS SYSTEM. Brain.
Cited by¶
1 citation across 1 artifact.
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Domain-specific¶
- Myelination
- Loss of myelin — the lesion in demyelinating disease such as multiple sclerosis and Guillain-Barré syndrome — produces correspondingly dramatic deficits in the affected pathway, and experimental demyelination establishes their physiology: focal slowing and temporal dispersion of the volley where the sheath is thinned, and outright conduction block where an internode or more is stripped, so the deficit tracks the severity of the lesion up to the point at which transmission fails altogether
This sourceThe controlled demonstration in experimental central demyelination that thinned myelin slows and disperses the conducted volley while loss of an internode or more blocks it outright, so the deficit tracks lesion severity up to the point of failure; the multiple sclerosis and Guillain-Barré attributions rest on separate clinical sources.
Supported in partVerified against the source
- Loss of myelin — the lesion in demyelinating disease such as multiple sclerosis and Guillain-Barré syndrome — produces correspondingly dramatic deficits in the affected pathway, and experimental demyelination establishes their physiology: focal slowing and temporal dispersion of the volley where the sheath is thinned, and outright conduction block where an internode or more is stripped, so the deficit tracks the severity of the lesion up to the point at which transmission fails altogether
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Registry ID ref:309620e06972 · see in the full table