Management of acute organophosphorus pesticide poisoning¶
Eddleston, M. (2008). Management of acute organophosphorus pesticide poisoning.
Cited by¶
2 citations across 2 artifacts.
Each citation links to the sentence it supports in the citing article.
Domain-specific¶
- Enzyme Inhibition
- Treatment combines atropine (blocking the muscarinic effects of excess acetylcholine) with an oxime such as pralidoxime, which can prise the phosphoryl group off and reactivate the enzyme — but only before "aging," a dealkylation that locks the inhibition permanently.
This sourceThat atropine plus an oxime such as pralidoxime is the standard management, and that oxime reactivation of phosphorylated acetylcholinesterase is possible only before aging locks the inhibition permanently.
- Treatment combines atropine (blocking the muscarinic effects of excess acetylcholine) with an oxime such as pralidoxime, which can prise the phosphoryl group off and reactivate the enzyme — but only before "aging," a dealkylation that locks the inhibition permanently.
- Pharmacodynamic Antagonism
- Clinicians titrate atropine to effect — escalating doses until secretions dry and oxygenation improves ("atropinization"), sometimes reaching very large cumulative doses in severe poisonings.
This sourceTitration of atropine to the endpoint of dried secretions and improved oxygenation ('atropinization'), including the very large cumulative doses used in severe organophosphate poisoning.
- Clinicians titrate atropine to effect — escalating doses until secretions dry and oxygenation improves ("atropinization"), sometimes reaching very large cumulative doses in severe poisonings.
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