Dollo's law and the death and resurrection of genes¶
Marshall, Raff, & Raff. (1994). Dollo's law and the death and resurrection of genes. Proceedings of the National Academy of Sciences.
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Domain-specific¶
- Dollo's Law
- Dollo's law (Louis Dollo, 1893) is the evolutionary generalization that a complex trait once lost in a lineage is overwhelmingly unlikely to re-evolve in identical form, because the genetic and developmental scaffolding that originally built it decays faster than selection can reassemble it
This sourceStates that Dollo's law treats evolution as not substantively reversible, because the degradation of genetic information is sufficiently fast that genes or developmental pathways released from selective pressure rapidly become nonfunctional. Model estimate that a silenced gene or lost developmental program has a significant probability of reactivation over evolutionary timescales of 0.5-6 million years, while genes unexpressed for more than 10 million years cannot be reactivated unless function is maintained by other selective constraints.
Supported in partVerified against the publisher's abstract
“Dollo's law, the concept that evolution is not substantively reversible, implies that the degradation of genetic information is sufficiently fast that genes or developmental pathways released from selective pressure will rapidly become nonfunctional.”
- Dollo's law (Louis Dollo, 1893) is the evolutionary generalization that a complex trait once lost in a lineage is overwhelmingly unlikely to re-evolve in identical form, because the genetic and developmental scaffolding that originally built it decays faster than selection can reassemble it
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Registry ID ref:31340605e8e4 · see in the full table