Combination therapy in combating cancer¶
Mokhtari, R. B., Homayouni, Baluch, Morgatskaya, Kumar, Das, & Yeger, H. (2017). Combination therapy in combating cancer. Oncotarget, 8(23), 38022-38043.
Cited by¶
1 citation across 1 artifact.
Each citation links to the sentence it supports in the citing article.
Primes¶
- Synergy and Antagonism
- Failure mode: a synergistic effect is observed, and a plausible mechanism is proposed (e.g., "complementary targets"), but the mechanism is never validated experimentally — a recurring pitfall Mokhtari and colleagues (2017) document in their review of cancer combination therapy, where pharmacodynamic claims often mask pharmacokinetic drivers.
This sourceReview of cancer combination therapy that catalogues mechanism-attribution failures in which observed synergistic effects later prove to be driven by pharmacokinetic interactions rather than the proposed pharmacodynamic complementation.
- Failure mode: a synergistic effect is observed, and a plausible mechanism is proposed (e.g., "complementary targets"), but the mechanism is never validated experimentally — a recurring pitfall Mokhtari and colleagues (2017) document in their review of cancer combination therapy, where pharmacodynamic claims often mask pharmacokinetic drivers.
Verification¶
Does it exist? Not checked yet. This entry carries no identifier to resolve. It was extracted from the citation as written in the article, normalized, and deduplicated against the rest of the registry.
Does it back the claim? Not recorded. The single citation of this work carries no recorded support check.
Was it audited? Yes. A second, independent pass read the citation against the article text and recorded a verdict.
Support is checked per citation rather than per work — the same source can be cited soundly in one article and wrongly in another. Per-citation recording began recently, so a citation with no recorded check is a gap in the record rather than evidence it went unchecked.
See how references were verified.
Registry ID ref:33fa2236dc11 · see in the full table