Combination therapy in combating cancer¶
Mokhtari, R. B., Homayouni, Baluch, Morgatskaya, Kumar, Das, & Yeger, H. (2017). Combination therapy in combating cancer. Oncotarget, 8(23), 38022-38043.
Cited by¶
1 citation across 1 artifact.
Each citation links to the sentence it supports in the citing article.
Primes¶
- Synergy and Antagonism
- Failure mode: a synergistic effect is observed, and a plausible mechanism is proposed (e.g., "complementary targets"), but the mechanism is never validated experimentally — a recurring pitfall Mokhtari and colleagues (2017) document in their review of cancer combination therapy, where pharmacodynamic claims often mask pharmacokinetic drivers.
This sourceReview of cancer combination therapy that catalogues mechanism-attribution failures in which observed synergistic effects later prove to be driven by pharmacokinetic interactions rather than the proposed pharmacodynamic complementation.
- Failure mode: a synergistic effect is observed, and a plausible mechanism is proposed (e.g., "complementary targets"), but the mechanism is never validated experimentally — a recurring pitfall Mokhtari and colleagues (2017) document in their review of cancer combination therapy, where pharmacodynamic claims often mask pharmacokinetic drivers.
Verification¶
This reference passed the adversarial substantiation pipeline: it was checked to exist and to support the claim it is attached to. See how references were verified.
Registry ID ref:33fa2236dc11 · see in the full table