Thiopental pharmacokinetics

Bischoff, K. B., & Dedrick, R. L. (1968). Thiopental pharmacokinetics. Journal of Pharmaceutical Sciences, 57(8), 1346-1351.

Type

Journal article

Intellectual base

Primary research

Year

1968

Link

https://doi.org/10.1002/jps.2600570814matched

Cited from

pharmacology_toxicology

Cited by

1 citation across 1 artifact.

Primes

• PK/PD Modeling (Pharmacokinetics / Pharmacodynamics)
  • T4: Extrapolation Beyond the Studied Range. PK/PD models are estimated in a specific population, dose range, and indication; extrapolating to higher doses, different populations (pediatric, geriatric, critically ill), or different indications invokes assumptions that the data do not support — a problem that motivated the physiologically-based PK approach Bischoff and Dedrick (1968) developed in their thiopental analysis to ground cross-population extrapolation in organ-blood-flow physiology.

Verification

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Registry ID ref:34b5696df922 · see in the full table