A Quantitative Description of Membrane Current and Its Application to Conduction and Excitation in Nerve.¶
Hodgkin, A. L., & Huxley, A. F. (1952). A Quantitative Description of Membrane Current and Its Application to Conduction and Excitation in Nerve. Journal of Physiology, 117(4), 500-544.
Cited by¶
5 citations across 4 artifacts.
Each citation links to the sentence it supports in the citing article.
Primes¶
- Amplification
- The Hodgkin-Huxley model
This sourceModels voltage-dependent ionic conductances generating and propagating the action potential; small perturbations are amplified into all-or-none spikes. SUPPORTS the axonal-signal-amplification claim.
- The Hodgkin-Huxley model
- Refractory Period
- Two sub-regimes are typically distinguished: an absolute refractory window, in which the action is flatly impossible, and a relative refractory window, in which the action is possible but requires a stronger-than-baseline stimulus.
This sourceEstablishes the action potential and sodium-channel inactivation as the mechanism of the absolute and relative refractory periods, the firing-rate ceiling, and one-way propagation.
- Two sub-regimes are typically distinguished: an absolute refractory window, in which the action is flatly impossible, and a relative refractory window, in which the action is possible but requires a stronger-than-baseline stimulus.
- Threshold
- When depolarization reaches approximately −55 mV (highly variable across cell types and conditions), voltage-gated sodium channels reach their activation threshold, a self-reinforcing depolarization cascade is triggered, and an action potential is generated, as Hodgkin and Huxley (1952) demonstrated quantitatively in their canonical voltage-clamp characterization of squid-axon membrane currents.
This sourceMathematical model of ionic conductance and action potential propagation in nerve axons; explains voltage-dependent amplification of small perturbations into large action potentials; biological instantiation of amplification principle.
- Listed in the references but not attached to a specific claim.
- When depolarization reaches approximately −55 mV (highly variable across cell types and conditions), voltage-gated sodium channels reach their activation threshold, a self-reinforcing depolarization cascade is triggered, and an action potential is generated, as Hodgkin and Huxley (1952) demonstrated quantitatively in their canonical voltage-clamp characterization of squid-axon membrane currents.
Mechanisms¶
- Cooldown or Refractory Window
- The idea borrows directly from the biological refractory period, in which a neuron that has just fired cannot fire again until it recovers.
This sourceDescribes the biological refractory period after neuronal firing during which another impulse cannot be initiated.
- The idea borrows directly from the biological refractory period, in which a neuron that has just fired cannot fire again until it recovers.
Verification¶
Does it exist? Confirmed. This work's DOI resolves to a registered record, which fixes its identity. That is all it fixes.
Does it back the claim? Not recorded. Neither this nor any other of the 5 citations of this work carries a recorded support check.
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Registry ID ref:35e19646924e · see in the full table