A Method for Estimating the Probability of Adverse Drug Reactions¶
Naranjo, C. A., Busto, U., Sellers, E. M., Sandor, P., Ruiz, I., Roberts, E. A., Janecek, E., et al. (1981). A Method for Estimating the Probability of Adverse Drug Reactions. Clinical Pharmacology and Therapeutics, 30(2), 239-245.
Cited by¶
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Mechanisms¶
- Washout and Rechallenge
- Its strength is turning a belief — "the inhibitor is working," or "the inhibitor caused this" — into evidence, cleanly separating the inhibitor's effect from natural drift and, as a bonus, exposing resistance when a rechallenge fails to reproduce the effect.
This sourceUses improvement after withdrawal and recurrence after readministration as evidence in adverse-drug-reaction causality assessment.
- Its strength is turning a belief — "the inhibitor is working," or "the inhibitor caused this" — into evidence, cleanly separating the inhibitor's effect from natural drift and, as a bonus, exposing resistance when a rechallenge fails to reproduce the effect.
Verification¶
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Registry ID ref:36cddc6e645b · see in the full table