Buprenorphine induces ceiling in respiratory depression but not in analgesia¶
Dahan, A. (2006). Buprenorphine induces ceiling in respiratory depression but not in analgesia. British Journal of Anaesthesia.
Cited by¶
1 citation across 1 artifact.
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Domain-specific¶
- Partial Agonist
- This dual character has direct clinical utility where full agonism is physiologically dangerous but complete blockade is also unacceptable: buprenorphine's partial agonism at the mu-opioid receptor provides analgesia and withdrawal suppression while imposing an intrinsic ceiling on respiratory depression that makes overdose dramatically less lethal than with morphine or heroin
This sourceExperimental evidence of a dose-independent ceiling in buprenorphine's respiratory-depressant effect, with no such ceiling in analgesia.
Supported in partVerified against a saved copy of the source
“While buprenorphine's analgesic effect increased significantly, respiratory depression was similar in magnitude and timing for the two doses tested.”
- This dual character has direct clinical utility where full agonism is physiologically dangerous but complete blockade is also unacceptable: buprenorphine's partial agonism at the mu-opioid receptor provides analgesia and withdrawal suppression while imposing an intrinsic ceiling on respiratory depression that makes overdose dramatically less lethal than with morphine or heroin
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