DNA Binding Sites

Stormo, G. D. (2000). DNA Binding Sites: Representation and Discovery. Bioinformatics, 16-23.

Type

Journal article

Intellectual base

Primary research

Year

2000

Pages

16-23

DOI

10.1093/bioinformatics/16.1.16

DOI registrant

Oxford University Press

Link

https://doi.org/10.1093/bioinformatics/16.1.16

Cited from

art_aesthetics

Cited by

1 citation across 1 artifact.

Primes

• Motif
  • Sequence-motif analysis in genomics maps cleanly: the corpus is a genome, the unit is a short consensus sequence such as a transcription-factor binding site (say, a TATA box), the permitted-transformation group is point-mutation within the consensus (the site tolerates some base substitutions while remaining functional), and the null model is the expected occurrence of the sequence in random DNA.

    Supported in partVerified against the publisher's abstract

    Stormo's abstract covers representing binding sites so new sequences can be searched, but says nothing about point-substitution tolerance of a consensus or a random-DNA null model.

    “The first is, given a collection of known binding sites, develop a representation of those sites that can be used to search new sequences and reliably predict where additional binding sites occur.”

    Read by an automated reader; not a human review. How support was checked

Verification

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Registry ID ref:3afc58692b78 · see in the full table