Trained Immunity¶
Netea, M. G., Joosten, L. A. B., Latz, E., Mills, K. H. G., Natoli, G., Stunnenberg, H. G., O’Neill, L. A. J., et al. (2016). Trained Immunity: A Program of Innate Immune Memory in Health and Disease. Science, 352(6284).
Cited by¶
1 citation across 1 artifact.
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Primes¶
- Metaplasticity
- In the immune system, trained immunity reprograms innate cells to respond more or less strongly to subsequent stimuli.
This sourceEstablishes trained immunity—innate immune cells reprogrammed by prior stimuli to respond more or less strongly to later challenges, a second-order modulation informing prime-boost schedules.
Supported in partVerified against the work's full text
Netea et al. present trained immunity as epigenetic reprogramming of innate cells toward stronger responses; dampened responses are attributed to tolerance, a related program.
“When one considers the traditional appraisal of the effects of tolerance as a hypo-inflammatory state, and trained immunity resulting in an increased production of proinflammatory cytokines, these two programs may seem to be functional opposites.”
- In the immune system, trained immunity reprograms innate cells to respond more or less strongly to subsequent stimuli.
Verification¶
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